Difference from Bile Duct Cancer and Relationship between Bile Duct Wall Thickness And Serum IgG/IgG4 Levels in IgG4-Related Sclerosing Cholangitis

Kuwatani, Masaki; Kawakami, Hiroshi; Zen, Yoh; Kawakubo, Kazumichi; Kudo, Taiki; Abe, Yoko; Kubo, Kimitoshi; Sakamoto, Naoya

Difference from Bile Duct Cancer and Relationship between Bile Duct Wall Thickness And Serum IgG/IgG4 Levels in IgG4-Related Sclerosing Cholangitis

Kuwatani, Masaki; Kawakami, Hiroshi; Zen, Yoh et al.

Hepato-Gastroenterology, 2014, 61(135), 1852-1856

Permalink : https://hdl.handle.net/2115/60252

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アクセス権	open access
URI	https://hdl.handle.net/2115/60252
タイトル	Difference from Bile Duct Cancer and Relationship between Bile Duct Wall Thickness And Serum IgG/IgG4 Levels in IgG4-Related Sclerosing Cholangitis
著者	Kuwatani, Masaki ; Kawakami, Hiroshi ; Zen, Yoh ; Kawakubo, Kazumichi ; Kudo, Taiki ; Abe, Yoko ; Kubo, Kimitoshi ; Sakamoto, Naoya
e-Rad_Researcher 50431375 著者名 Kuwatani, Masaki
e-Rad_Researcher 80399823 著者名 Kawakami, Hiroshi
e-Rad_Researcher 90377416 著者名 Zen, Yoh
著者名 Kawakubo, Kazumichi
著者名 Kudo, Taiki
著者名 Abe, Yoko
著者名 Kubo, Kimitoshi
e-Rad_Researcher 10334418 著者名 Sakamoto, Naoya
言語	英語
キーワード	IgG4-related sclerosing cholangitis
	IgG4
	IgG
	bile duct
	intraductal ultrasonography
発行日	2014-10
出版者	Thieme
収録物名	Hepato-Gastroenterology
巻(号)	61(135)
ページ	1852-1856
抄録	Background/Aims: IgG4-related sclerosing cholangitis (IgG4-SC) is a newly established entity. The purpose of this study was to investigate the differences in intraductal ultrasonography (IDUS) findings between IgG4-SC and bile duct (BD) cancer (BDC) as well as the relationship among BD wall thickness, serological and pathological findings in IgG4-SC. Methodology: Based on the diagnostic criteria of IgG4-SC, we reviewed patients in our hospital between April 2005 and June 2013, and analyzed the data obtained from 32 patients with IgG4-SC and 40 patients with BDC. Results: Regarding IDUS findings, significantly more cases in BDC indicated rigid/papillary inner margin than in IgG4-SC, while biopsy was more efficient. There were no significant correlations between BD wall thickness and serum IgG/IgG4 levels or the number of IgG4-positive cells of the BD specimens. All the IgG4-SC patients without steroid treatment revealed discordant results in the shifts of IgG, IgG4 and BD wall thickness between the 1st and 2nd examinations, while all patients with steroid had completely concordant results of the shifts. Conclusions: IDUS findings alone are insufficient for differentiation between IgG4-SC and BDC. BD wall thickness, serum IgG and IgG4 proportionally shift and reflect the effect of steroid on IgG4-SC after steroid treatment, not before it.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0172-6390
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.5754/hge14546