The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer

Dong, Peixin; Konno, Yosuke; Watari, Hidemichi; Hosaka, Masayoshi; Noguchi, Masayuki; Sakuragi, Noriaki

The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer

Dong, Peixin; Konno, Yosuke; Watari, Hidemichi et al.

Journal of Translational Medicine, 2014, 12(1), 231

Permalink : https://hdl.handle.net/2115/60533

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アクセス権	open access
URI	https://hdl.handle.net/2115/60533
タイトル	The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer
著者	Dong, Peixin ; Konno, Yosuke ; Watari, Hidemichi ; Hosaka, Masayoshi ; Noguchi, Masayuki ; Sakuragi, Noriaki
著者名 Dong, Peixin
著者名 Konno, Yosuke
e-Rad_Researcher 10344508 著者名 Watari, Hidemichi
著者名 Hosaka, Masayoshi
e-Rad_Researcher 40359477 著者名 Noguchi, Masayuki
e-Rad_Researcher 70153963 著者名 Sakuragi, Noriaki
言語	英語
キーワード	Microrna
	PI3K
	PTEN
	AKT
	mTOR
	EMT
	Invasion
	Cancer stem cell
	Chemoresistance
	Endometrial cancer
発行日	2014-08-21
出版者	BioMed Central
収録物名	Journal of Translational Medicine
巻(号)	12(1)
ページ	231
抄録	Activation of the PI3K/AKT pathway, a common mechanism in all subtypes of endometrial cancers (endometrioid and non-endometrioid tumors), has important roles in contributing to epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) features. MicroRNAs (miRNAs) are small non-coding RNA molecules that concurrently affect multiple target genes, and regulate a wide range of genes involved in modulating EMT and CSC properties. Here we overview the recent advances revealing the impact of miRNAs on EMT and CSC phenotypes in tumors including endometrial cancer via regulating PI3K/AKT pathway. MiRNAs are crucial mediators of EMT and CSC through targeting PTEN-PI3K-AKT-mTOR axis. In endometrial cancer cells, miRNAs can activate or attenuate EMT and CSC by targeting PTEN and other EMT-associated genes, such as Twist1, ZEB1 and BMI-1. More detailed studies of miRNAs will deepen our understanding of the molecular basis underlying PI3K/AKT-induced endometrial cancer initiation and progression. Targeting key signaling components of PI3K/AKT pathway by restoring or inhibiting miRNA function holds promise as a potential therapeutic approach to suppress EMT and CSC in endometrial cancer.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1479-5876
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12967-014-0231-0