MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells

Konno, Yosuke; Dong, Peixin; Xiong, Ying; Suzuki, Fumihiko; Lu, Jiabin; Cai, Muyan; Watari, Hidemichi; Mitamura, Takashi; Hosaka, Masayoshi; Hanley, Sharon J. B.; Kudo, Masataka; Sakuragi, Noriaki

MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells

Konno, Yosuke; Dong, Peixin; Xiong, Ying et al.

Oncotarget, 2014, 5(15), 6049-6062

Permalink : https://hdl.handle.net/2115/60536

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アクセス権	open access
URI	https://hdl.handle.net/2115/60536
タイトル	MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells
著者	Konno, Yosuke ; Dong, Peixin ; Xiong, Ying ; Suzuki, Fumihiko ; Lu, Jiabin ; Cai, Muyan ; Watari, Hidemichi ; Mitamura, Takashi ; Hosaka, Masayoshi ; Hanley, Sharon J. B. ; Kudo, Masataka ; Sakuragi, Noriaki
著者名 Konno, Yosuke
著者名 Dong, Peixin
著者名 Xiong, Ying
e-Rad_Researcher 20400343 著者名 Suzuki, Fumihiko
著者名 Lu, Jiabin
著者名 Cai, Muyan
e-Rad_Researcher 10344508 著者名 Watari, Hidemichi
著者名 Mitamura, Takashi
著者名 Hosaka, Masayoshi
e-Rad_Researcher 80529412 著者名 Hanley, Sharon J. B.
著者名 Kudo, Masataka
e-Rad_Researcher 70153963 著者名 Sakuragi, Noriaki
言語	英語
キーワード	microRNA-101
	proliferation
	EMT
	EZH2
	MCL-1
	FOS
発行日	2014-07-02
出版者	Impact Journals
収録物名	Oncotarget
巻(号)	5(15)
ページ	6049-6062
抄録	MicroRNA-101 has been implicated as a tumor suppressor miRNA in human tumors. However, its potential functional impact and the underlying mechanisms in endometrial cancer progression have not been determined. Here, we report that in aggressive endometrial cancer cells, re-expression of microRNA-101 leads to inhibition of cell proliferation and induction of apoptosis and senescence. Ectopic overexpression of microRNA-101 attenuates the epithelial-mesenchymal transition-associated cancer cell migration and invasion, abrogates the sphere-forming capacity and enhances chemosensitivity to paclitaxel. Algorithm and microarray-based strategies identifies potential microRNA-101 targets. Among these, we validated EZH2, MCL-1 and FOS as direct targets of miR-101 and silencing of these genes mimics the tumor suppressive effects observed on promoting microRNA-101 function. Importantly, further results suggest an inverse correlation between low miR-101 and high EZH2, MCL-1 and FOS expression in EC specimens. We conclude that, as a crucial tumor suppressor, microRNA-101 suppresses cell proliferation, invasiveness and self-renewal in aggressive endometrial cancer cells via modulating multiple critical oncogenes. The microRNA-101-EZH2/MCL-1/FOS axis is a potential therapeutic target for endometrial cancer.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
PISSN	1949-2553
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.18632/oncotarget.2157