Urinary protein-to-creatinine ratio in pregnant women after dipstick testing : prospective observational study

Baba, Yosuke; Yamada, Takahiro; Obata-Yasuoka, Mana; Yasuda, Shun; Ohno, Yasumasa; Kawabata, Kosuke; Minakawa, Shiori; Hirai, Chihiro; Kusaka, Hideto; Murabayashi, Nao; Inde, Yusuke; Nagura, Michikazu; Hamada, Hiromi; Itakura, Atsuo; Ohkuchi, Akihide; Maeda, Makoto; Sagawa, Norimasa; Nakai, Akihito; Kataoka, Soromon; Fujimori, Keiya; Kudo, Yoshiki; Ikeda, Tomoaki; Minakami, Hisanori

Urinary protein-to-creatinine ratio in pregnant women after dipstick testing : prospective observational study

Baba, Yosuke; Yamada, Takahiro; Obata-Yasuoka, Mana et al.

BMC Pregnancy and Childbirth, 2015, 15, 331

Permalink : https://hdl.handle.net/2115/60538

このアイテムのアクセス数:938件（2026-08-16 20:13 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
s12884-015-0776-9	pdf	716 KB	783

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/60538
タイトル	Urinary protein-to-creatinine ratio in pregnant women after dipstick testing : prospective observational study
著者	Baba, Yosuke ; Yamada, Takahiro ; Obata-Yasuoka, Mana ; Yasuda, Shun ; Ohno, Yasumasa ; Kawabata, Kosuke ; Minakawa, Shiori ; Hirai, Chihiro ; Kusaka, Hideto ; Murabayashi, Nao ; Inde, Yusuke ; Nagura, Michikazu ; Hamada, Hiromi ; Itakura, Atsuo ; Ohkuchi, Akihide ; Maeda, Makoto ; Sagawa, Norimasa ; Nakai, Akihito ; Kataoka, Soromon ; Fujimori, Keiya ; Kudo, Yoshiki ; Ikeda, Tomoaki ; Minakami, Hisanori
著者名 Baba, Yosuke
e-Rad_Researcher 20419948 著者名 Yamada, Takahiro
e-Rad_Researcher 20420086 著者名 Obata-Yasuoka, Mana
著者名 Yasuda, Shun
著者名 Ohno, Yasumasa
著者名 Kawabata, Kosuke
著者名 Minakawa, Shiori
著者名 Hirai, Chihiro
e-Rad_Researcher 70332715 著者名 Kusaka, Hideto
e-Rad_Researcher 10378416 著者名 Murabayashi, Nao
著者名 Inde, Yusuke
著者名 Nagura, Michikazu
著者名 Hamada, Hiromi
e-Rad_Researcher 70262897 著者名 Itakura, Atsuo
e-Rad_Researcher 10306136 著者名 Ohkuchi, Akihide
著者名 Maeda, Makoto
e-Rad_Researcher 00162321 著者名 Sagawa, Norimasa
e-Rad_Researcher 20227721 著者名 Nakai, Akihito
著者名 Kataoka, Soromon
e-Rad_Researcher 80285030 著者名 Fujimori, Keiya
e-Rad_Researcher 80241082 著者名 Kudo, Yoshiki
e-Rad_Researcher 80202894 著者名 Ikeda, Tomoaki
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
言語	英語
キーワード	Gestational hypertension
	Kidney function
	Preeclampsia prediction
	Protein creatinine ratio
	Proteinuria pregnancy
	Urine dipstick
発行日	2015-12-14
出版者	BioMed Central
収録物名	BMC Pregnancy and Childbirth
巻(号)	15
ページ	331
抄録	Background: The dipstick test is widely used as a primary screening test for detection of significant proteinuria in pregnancy (SPIP). However, it often shows a false positive test result. This study was performed to determine which pregnant women should be recommended to undergo determination of urinary protein-to-creatinine ratio (mg/mg, P/Cr test) after dipstick test for confirmation of SPIP. Methods: This was a multicenter, prospective, and observational study of 2212 urine specimens from 1033 pregnant women who underwent simultaneous dipstick and P/Cr tests in the same spot urine samples at least once. SPIP was defined as P/Cr > 0.27. Preeclampsia was diagnosed in women with both hypertension and SPIP. Results: Preeclampsia, hypertension alone, and SPIP alone developed in 202 (20 %), 73 (7.1 %), and 120 (12 %) women, respectively. Creatinine concentration [Cr] varied greatly, ranging from 8.1 to 831 mg/dL in the 2212 urine samples. Rate of positive dipstick test results increased with increasing [Cr], while SPIP prevalence rate was lower in urine samples with higher [Cr], yielding higher false positive rates in samples with higher [Cr]. Postpartum urine samples had significantly lower [Cr] compared to those obtained antepartum (60 [8.7-297] vs. 100 [10-401] mg/dL, respectively). At the first P/Cr test among women with similar dipstick test results, the risk of having SPIP was consistently and significantly higher for hypertensive women than for normotensive women at any dipstick test result: 18 % (14/77) vs. 3.2 % (8/251), 47 % (26/55) vs. 8.7 % (37/425), 91 % (82/90) vs. 59 % (44/75) for negative/equivocal, 1+, and >= 2+ test results, respectively. The risk of SPIP was 16 % (9/55) for normotensive women when two successive antenatal urine samples showed a dipstick test result of 1 +. Conclusions: For prediction of SPIP, the dipstick test was more likely to show a false positive result in concentrated urine samples with higher [Cr]. Hypertensive women with >= 1+ as well as normotensive women with >= 2+ on dipstick test should be advised to undergo the P/Cr test.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1471-2393
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12884-015-0776-9