Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses

Sasaki, Michihito; Orba, Yasuko; Ueno, Keisuke et al.

Journal of General Virology, 2015, 96(2), 440-452

Permalink : https://hdl.handle.net/2115/60630

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アクセス権
open access
URI
https://hdl.handle.net/2115/60630
タイトル
Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses
著者
Sasaki, Michihito ; Orba, Yasuko ; Ueno, Keisuke ; Ishii, Akihiro ; Moonga, Ladslav ; Hang'ombe, Bernard M. ; Mweene, Aaron S. ; Ito, Kimihito ; Sawa, Hirofumi
e-Rad_Researcher
70609403
著者名
Sasaki, Michihito
e-Rad_Researcher
60507169
著者名
Orba, Yasuko
e-Rad_Researcher
90435983
著者名
Ueno, Keisuke
e-Rad_Researcher
90421982
著者名
Ishii, Akihiro
著者名
Moonga, Ladslav
著者名
Hang'ombe, Bernard M.
著者名
Mweene, Aaron S.
e-Rad_Researcher
60396314
著者名
Ito, Kimihito
e-Rad_Researcher
30292006
著者名
Sawa, Hirofumi
言語
英語
発行日
2015-02
出版者
Society for General Microbiology
収録物名
Journal of General Virology
巻(号)
96(2)
ページ
440-452
抄録
Shrews are small insectivorous mammals that are distributed worldwide. Similar to rodents, shrews live on the ground and are commonly found near human residences. In this study, we investigated the enteric virome of wild shrews in the genus Crocidura using a sequence-independent viral metagenomics approach. A large portion of the shrew enteric virome was composed of insect viruses, whilst novel viruses including cyclovirus, picornavirus and picorna-like virus were also identified. Several cycloviruses, including variants of human cycloviruses detected in cerebrospinal fluid and stools, were detected in wild shrews at a high prevalence rate. The identified picornavirus was distantly related to human parechovirus, inferring the presence of a new genus in this family. The identified picorna-like viruses were characterized as different species of calhevirus 1, which was discovered previously in human stools. Complete or nearly complete genome sequences of these novel viruses were determined in this study and then were subjected to further genetic characterization. Our study provides an initial view of the diversity and distinctiveness of the shrew enteric virome and highlights unique novel viruses related to human stool-associated viruses.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0022-1317
EISSN
1465-2099
NCID
AA00698722
関連情報
PMID
25381053
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1099/vir.0.071209-0