Glucocorticoids Reset the Nasal Circadian Clock in Mice

Honma, Aya; Yamada, Yoshiko; Nakamaru, Yuji et al.

Endocrinology, 2015, 156(11), 4302-4311

Permalink : https://hdl.handle.net/2115/60748

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アクセス権
open access
URI
https://hdl.handle.net/2115/60748
タイトル
Glucocorticoids Reset the Nasal Circadian Clock in Mice
著者
Honma, Aya ; Yamada, Yoshiko ; Nakamaru, Yuji ; Fukuda, Satoshi ; Honma, Ken-ichi ; Honma, Sato
著者名
Honma, Aya
著者名
Yamada, Yoshiko
著者名
Nakamaru, Yuji
e-Rad_Researcher
20125347
著者名
Fukuda, Satoshi
e-Rad_Researcher
40113625
著者名
Honma, Ken-ichi
e-Rad_Researcher
20142713
著者名
Honma, Sato
言語
英語
発行日
2015-11
出版者
Endocrine Society
収録物名
Endocrinology
巻(号)
156(11)
ページ
4302-4311
抄録
The symptoms of allergic rhinitis show marked day-night changes that are likely to be under the control of the circadian clock, but the mechanism of this control is poorly understood. Because most peripheral tissues have endogenous circadian clocks, we examined the circadian rhythm of the clock gene product PERIOD2 (PER2) in the nasal mucosa of male mice using a luciferase reporter and demonstrated for the first time the phase-dependent effects of dexamethasone (DEX) on nasal PER2 rhythm in vivo and ex vivo. The phase shifts in PER2 rhythm caused by DEX were observed around the peak phase of serum glucocorticoids, suggesting that the circadian rhythm of endogenous glucocorticoids regulates the peripheral clock of the mouse nasal mucosa. From the viewpoint of circadian physiology, the best time to administer intranasal steroid treatment for allergic rhinitis would be when no phase shift is caused by DEX: in the early evening in diurnal humans.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0013-7227
関連情報
PMID
26360505
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1210/en.2015-1490