炭酸カルシウムまたはα-TCPを複合化した4-META/MMA-TBBレジン上への新生骨の接触

α-TCP

北海道歯学会

北海道歯学雑誌

4-META/MMA-TBB resin (SuperBond, Sun Medical) has been used for root-end sealing following apicoectomy and the bonding treatment of vertical root fractures as it results in high strength and biocompatible. However hard tissue is rarely formed by the resin. New bone formation was reported to have been observed directly on cured resin containing calcium carbonate. In this study, we evaluated bone formation on the surface of 4-META/MMA-TBB resin containing calcium carbonate or α-TCP. 　To create the implantation rods, SuperBond was cured anaerobically in a polypropylene tube that was 1 mm in diameter and broken into segments that were 5 mm in length. The right and left femur of Wistar rats were trephined to create a medullary cavity that was 1 mm in diameter, and the rods were implanted after resin was applied : calcium carbonate or α -TCP were mixed with the polymer powder of SuperBond at 0, 40, and 60 wt%, and then mixed with monomer and an initiator. Histological specimens were prepared at 2 and 8 weeks post-operation and the sections were stained with H-E. Measurements including both the rates of bone formation and the direct contact of new bone with the resin were taken. 　Two weeks following implantation, newly-formed bone was observed in the surrounding area of the implanted rods, and few inflammatory cells were found in the five groups. Newly formed bone was not directly in contact with the samples. The soft tissue was thin at eight weeks. The newly formed bone was directly in contact with all samples. The rates of bone-resin contact were 2.6±0.5% (0% group), 0±4.8% (calcium carbonate 40% group), 0% (calcium carbonate 60% group), 14.0±5.0% (α-TCP 40% group), 28.3±14.4 (α-TCP 60% group) respectively. The α-TCP 40% group showed a statistically significant difference compared with the 0% and the calcium carbonate 60% group. The Theα-TCP 60% group showed a statistically significant difference compared with the 0%, the calcium carbonate 40% and 60% group. 　These results suggested that α-TCP filler in cured 4-META/MMA-TBB resin can facilitate direct contact with bone.