Applications of CRSIPR/Cas9 in Cancer Research

Yue, Junming; Du, Ziyun; Zhou, Fu-Ming et al.

Cancer Medicine & Anti Cancer Drugs, 2016, 1(1), 1000103

Permalink : https://hdl.handle.net/2115/61465

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アクセス権	open access
URI	https://hdl.handle.net/2115/61465
タイトル	Applications of CRSIPR/Cas9 in Cancer Research
著者	Yue, Junming ; Du, Ziyun ; Zhou, Fu-Ming ; Dong, Peixin ; Pfeffer, Lawrence M
著者名 Yue, Junming
著者名 Du, Ziyun
著者名 Zhou, Fu-Ming
e-Rad_Researcher 50602504 著者名 Dong, Peixin
著者名 Pfeffer, Lawrence M
言語	英語
キーワード	Cancer
	CRISPR/Cas9
	Application
発行日	2016-03
出版者	OMICS International
収録物名	Cancer Medicine & Anti Cancer Drugs
巻(号)	1(1)
ページ	1000103
抄録	The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record