The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis

Manabe, Osamu; Yoshinaga, Keiichiro; Ohira, Hiroshi; Masuda, Atsuro; Sato, Takahiro; Tsujino, Ichizo; Yamada, Asuka; Oyama-Manabe, Noriko; Hirata, Kenji; Nishimura, Masaharu; Tamaki, Nagara

The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis

Manabe, Osamu; Yoshinaga, Keiichiro; Ohira, Hiroshi et al.

Journal of nuclear cardiology, 2016, 23(2), 244-252

Permalink : https://hdl.handle.net/2115/61494

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アクセス権	open access
URI	https://hdl.handle.net/2115/61494
タイトル	The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis
著者	Manabe, Osamu ; Yoshinaga, Keiichiro ; Ohira, Hiroshi ; Masuda, Atsuro ; Sato, Takahiro ; Tsujino, Ichizo ; Yamada, Asuka ; Oyama-Manabe, Noriko ; Hirata, Kenji ; Nishimura, Masaharu ; Tamaki, Nagara
e-Rad_Researcher 40443957 著者名 Manabe, Osamu
e-Rad_Researcher 30435961 著者名 Yoshinaga, Keiichiro
著者名 Ohira, Hiroshi
著者名 Masuda, Atsuro
著者名 Sato, Takahiro
e-Rad_Researcher 00344507 著者名 Tsujino, Ichizo
著者名 Yamada, Asuka
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 30431365 著者名 Hirata, Kenji
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	Cardiac sarcoidosis
	18F-fluorodeoxyglucose
	positron emission tomography
	long fasting
	free fatty acid
発行日	2016-04
出版者	Springer
収録物名	Journal of nuclear cardiology
巻(号)	23(2)
ページ	244-252
抄録	Background. 18F-fluorodeoxyglucose (FDG) PET plays an important role in the detection of cardiac involvement sarcoidosis (CS). However, diffuse left ventricle (LV) wall uptake sometimes makes it difficult to distinguish between positive uptake and physiological uptake. The aims of this study were to evaluate the effects of 18-h fasting with low-carbohydrate diet (LCD) vs a minimum of 6-h fasting preparations on diffuse LV FDG uptake and free fatty acid (FFA) levels in patients with suspected CS. Methods. Eighty-two patients with suspected CS were divided into 2 preparation protocols: one with a minimum 6-h fast without LCD preparation (group A, n = 58) and the other with a minimum 18-h fast with LCD preparation (group B, n = 24). All patients also received intravenous unfractionated heparin (UFH; 50 IU/kg) before the injection of FDG. Results. Group A showed a higher percentage of diffuse LV uptake than did group B (27.6 vs 0.0%, P = .0041). Group B showed higher FFA levels (1159.1 ± 393.0, 650.5 ± 310.9 μEq/L, P < .0001) than did group A. Patients with diffuse LV uptake (n = 16) showed lower FFA levels than did other patients (n = 66) (432.1 ± 296.1, 888.4 ± 381.4 μEq/L, P < .0001). UFH administration significantly increased FFAs in both groups, even in the patients with diffuse LV FDG uptake. Conclusions. The 18-h fast with LCD preparation significantly reduced diffuse LV uptake and increased FFA levels. In particular, the FFA level was significantly lower in patients with LV diffuse uptake than in patients without LV diffuse uptake. Acutely increasing plasma FFA through the use of UFH may not have a significant role in reducing physiological LV FDG uptake.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1071-3581
NCID	AA11016223
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1007/s12350-015-0226-0