Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)

Harada, Keiichi; Katoh, Norio; Suzuki, Ryusuke; Ito, Yoichi M.; Shimizu, Shinichi; Onimaru, Rikiya; Inoue, Tetsuya; Miyamoto, Naoki; Shirato, Hiroki

Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)

Harada, Keiichi; Katoh, Norio; Suzuki, Ryusuke et al.

Physica medica : European journal of medical physics, 2016, 32(2), 305-311

Permalink : https://hdl.handle.net/2115/61917

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/61917
タイトル	Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)
著者	Harada, Keiichi ; Katoh, Norio ; Suzuki, Ryusuke ; Ito, Yoichi M. ; Shimizu, Shinichi ; Onimaru, Rikiya ; Inoue, Tetsuya ; Miyamoto, Naoki ; Shirato, Hiroki
著者名 Harada, Keiichi
e-Rad_Researcher 80572495 著者名 Katoh, Norio
e-Rad_Researcher 00400052 著者名 Suzuki, Ryusuke
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 10431363 著者名 Inoue, Tetsuya
e-Rad_Researcher 00552879 著者名 Miyamoto, Naoki
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Four-dimensional computed tomography
	Stereotactic body radiation therapy
	Real-time tumor-tracking radiotherapy
	Organ motion
発行日	2016-02
出版者	Elsevier
収録物名	Physica medica : European journal of medical physics
巻(号)	32(2)
ページ	305-311
抄録	Purpose: We investigated the usefulness of four-dimensional computed tomography (4DCT) performed before stereotactic body radiation therapy (SBRT) in determining the internal margins for peripheral lung tumors. Methods and Materials: The amplitude of the movement of a fiducial marker near a lung tumor measured using the maximum intensity projection (MIP) method in 4DCT imaging was acquired before the SBRT (Amp(CT)) and compared with the mean amplitude of the marker movement during SBRT (Amp(mean)) and with the maximum amplitude of the marker movement during SBRT (Amp(max)) using a real-time tumortracking radiotherapy (RTRT) system with 22 patients. Results: There were no significant differences between the means of the Amp(mean) and the means of the Amp(CT) in all directions (LR, P = 0.45; CC, P = 0.80; AP, P = 0.65). The means of the Amp(max) were significantly larger than the means of the Amp(CT) in all directions (LR, P < 0.01; CC, P = 0.03; AP, P < 0.01). In the lower lobe, the mean difference of the Amp(CT) from the mean of the Amp(max) was 5.7 +/- 8.0 mm, 12.5 +/- 16.7 mm, and 6.8 +/- 8.5 mm in the LR, CC, and AP directions, respectively. Conclusions: Acquiring 4DCT MIP images before the SBRT treatment is useful to establish the mean amplitude for a patient during SBRT but it underestimates the maximum amplitude during actual SBRT. Caution must be paid to determine the margin with the 4DCT especially for tumors at the lower lobe where it is of the potentially greatest benefit.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1120-1797
関連情報	PMID 26944253
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.ejmp.2015.10.093