Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose

Miyoshi, Arina; Yamada, Mai; Shida, Haruki; Nakazawa, Daigo; Kusunoki, Yoshihiro; Nakamura, Akinobu; Miyoshi, Hideaki; Tomaru, Utano; Atsumi, Tatsuya; Ishizu, Akihiro

Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose

Miyoshi, Arina; Yamada, Mai; Shida, Haruki et al.

Pathobiology, 2016, 83(5), 243-251

Permalink : https://hdl.handle.net/2115/61981

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アクセス権	open access
URI	https://hdl.handle.net/2115/61981
タイトル	Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose
著者	Miyoshi, Arina ; Yamada, Mai ; Shida, Haruki ; Nakazawa, Daigo ; Kusunoki, Yoshihiro ; Nakamura, Akinobu ; Miyoshi, Hideaki ; Tomaru, Utano ; Atsumi, Tatsuya ; Ishizu, Akihiro
著者名 Miyoshi, Arina
著者名 Yamada, Mai
著者名 Shida, Haruki
著者名 Nakazawa, Daigo
著者名 Kusunoki, Yoshihiro
e-Rad_Researcher 70552420 著者名 Nakamura, Akinobu
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
e-Rad_Researcher 20360901 著者名 Tomaru, Utano
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
e-Rad_Researcher 60321957 著者名 Ishizu, Akihiro
言語	英語
キーワード	Aldose reductase inhibitor
	Microvascular complications
	Myeloperoxidase-DNA complex
	Neutrophil extracellular trap
	Polyol pathway
	Type 2 diabetes
発行日	2016
出版者	Karger
収録物名	Pathobiology
巻(号)	83(5)
ページ	243-251
抄録	Objectives: Although intensive therapy for type 2 diabetes (T2D) prevents microvascular complications, 10% of well-controlled T2D patients develop microangiopathy. Therefore, the identification of risk markers for microvascular complications in well-controlled T2D patients is important. Recent studies have demonstrated that high-dose glucose induces neutrophil extracellular trap (NET) formation, which can be a risk for microvascular disorders. Thus, we attempted to determine the correlation of circulating NET levels with clinical/laboratory parameters in well-controlled T2D patients and to reveal the mechanism of NET formation induced by high-dose glucose. Methods: Circulating NET levels represented by myeloperoxidase (MPO)-DNA complexes in the serum of 11 well-controlled T2D patients and 13 healthy volunteers were determined by enzyme-linked immunosorbent assay. The pathway involved in the NET formation induced by high-dose glucose was determined using specific inhibitors. Results: Serum MPO-DNA complex levels were significantly higher in some well-controlled T2D patients in correlation with the clinical/laboratory parameters which have been regarded as risk markers for microvascular complications. The aldose reductase inhibitor, ranirestat, could inhibit the NET formation induced by high-dose glucose. Conclusions: Elevated levels of circulating NETs can be a risk marker for microvascular complications in well-controlled T2D patients. The polyol pathway is involved in the NET formation induced by high-dose glucose.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016 The Author(s) Published by S. Karger AG, Basel
PISSN	1015-2008
EISSN	1423-0291
NCID	AA1077272X
関連情報	PMID 27189166
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1159/000444881