Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma

Mizumachi, Takatsugu; Homma, Akihiro; Kakizaki, Tomohiko; Sakashita, Tomohiro; Kano, Satoshi; Hatakeyama, Hiromitsu; Tsuchiya, Kazuhiko; Yasuda, Koichi; Onimaru, Rikiya; Shirato, Hiroki; Taguchi, Jun; Shimizu, Yasushi; Kinoshita, Ichiro; Akita, Hirotoshi; Fukuda, Satoshi

Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma

Mizumachi, Takatsugu; Homma, Akihiro; Kakizaki, Tomohiko et al.

International journal of clinical oncology, 2015, 20(3), 431-437

Permalink : https://hdl.handle.net/2115/61985

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アクセス権	open access
URI	https://hdl.handle.net/2115/61985
タイトル	Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma
著者	Mizumachi, Takatsugu ; Homma, Akihiro ; Kakizaki, Tomohiko ; Sakashita, Tomohiro ; Kano, Satoshi ; Hatakeyama, Hiromitsu ; Tsuchiya, Kazuhiko ; Yasuda, Koichi ; Onimaru, Rikiya ; Shirato, Hiroki ; Taguchi, Jun ; Shimizu, Yasushi ; Kinoshita, Ichiro ; Akita, Hirotoshi ; Fukuda, Satoshi
e-Rad_Researcher 00507577 著者名 Mizumachi, Takatsugu
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
著者名 Kakizaki, Tomohiko
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
e-Rad_Researcher 60580892 著者名 Tsuchiya, Kazuhiko
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
著者名 Taguchi, Jun
e-Rad_Researcher 10374513 著者名 Shimizu, Yasushi
e-Rad_Researcher 40343008 著者名 Kinoshita, Ichiro
e-Rad_Researcher 70222528 著者名 Akita, Hirotoshi
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
キーワード	Head and neck cancer
	Induction chemotherapy
	Chemoradiotherapy
発行日	2015-06
出版者	Springer
収録物名	International journal of clinical oncology
巻(号)	20(3)
ページ	431-437
抄録	The aim of this study was to evaluate the feasibility of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy followed by concurrent weekly cisplatin chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Between 2010 and 2013, 30 patients with Stage IV HNSCC were treated in Hokkaido University Hospital with three cycles of induction chemotherapy (docetaxel 75 mg/m(2) and cisplatin 75 mg/m(2), day 1; and 5-fluorouracil 750 mg/m(2)/day 120 h continuous infusion, every 3 weeks) followed by concurrent weekly cisplatin (40 mg/m(2), on weeks 1, 2, 3, 5, 6 and 7) chemoradiotherapy. Three courses of induction chemotherapy were performed in 25 patients (83 %) with grade 3-4 toxicities during induction chemotherapy observed in 22 patients (73 %). The major toxicities were hematologic, with 22 cases (73 %) showing grade 3-4 neutropenia. Radiotherapy was completed (70 Gy) in 29 patients (97 %), while a total of 19 patients (63 %) completed five (13 patients) or six (6 patients) courses of chemotherapy. During concurrent chemoradiotherapy, no grade 4 hematological toxicities were observed. Grade 4 dermatitis was observed in one patient, and grade 3 mucositis was observed in 12 patients. There were no treatment-related deaths during the induction chemotherapy or concurrent chemoradiotherapy. The 1- and 2-year progression-free survival rates and the 1- and 2-year overall survival rates were 86 %, 72 %, and 89 %, 81 %, respectively. Sequential therapy composed of induction chemotherapy followed by concurrent weekly cisplatin chemoradiotherapy is feasible, showing encouraging results in patients with locally advanced HNSCC. Concurrent weekly cisplatin chemoradiotherapy following induction chemotherapy appears to be a suitable alternative to three-weekly high-dose cisplatin therapy.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at Springer via http://dx.doi.org/10.1007/s10147-014-0726-y
PISSN	1341-9625
関連情報	PMID 24993675
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10147-014-0726-y