Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

Tanaka, Kimitaka; Tsuchikawa, Takahiro; Miyamoto, Masaki; Maki, Takehiro; Ichinokawa, Masaomi; Kubota, Kanako C.; Shichinohe, Toshiaki; Hirano, Satoshi; Ferrone, Soldano; Dosaka-Akita, Hirotoshi; Matsuno, Yoshihiro; Kondo, Satoshi

Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

Tanaka, Kimitaka; Tsuchikawa, Takahiro; Miyamoto, Masaki et al.

International Journal of Oncology, 2012, 40(4), 965-974

Permalink : https://hdl.handle.net/2115/62038

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アクセス権	open access
URI	https://hdl.handle.net/2115/62038
タイトル	Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients
著者	Tanaka, Kimitaka ; Tsuchikawa, Takahiro ; Miyamoto, Masaki ; Maki, Takehiro ; Ichinokawa, Masaomi ; Kubota, Kanako C. ; Shichinohe, Toshiaki ; Hirano, Satoshi ; Ferrone, Soldano ; Dosaka-Akita, Hirotoshi ; Matsuno, Yoshihiro ; Kondo, Satoshi
著者名 Tanaka, Kimitaka
e-Rad_Researcher 50507572 著者名 Tsuchikawa, Takahiro
e-Rad_Researcher 40333611 著者名 Miyamoto, Masaki
著者名 Maki, Takehiro
著者名 Ichinokawa, Masaomi
著者名 Kubota, Kanako C.
e-Rad_Researcher 70374353 著者名 Shichinohe, Toshiaki
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
著者名 Ferrone, Soldano
著者名 Dosaka-Akita, Hirotoshi
著者名 Matsuno, Yoshihiro
e-Rad_Researcher 30215454 著者名 Kondo, Satoshi
言語	英語
キーワード	histocompatibility antigens class I
	antigen processing machinery
	esophageal neoplasms
	tissue array analysis
	immunohistochemistry
発行日	2012-04
出版者	Spandidos Publications
収録物名	International Journal of Oncology
巻(号)	40(4)
ページ	965-974
抄録	The HLA class I antigen processing machinery (APM) plays a crucial role in the anticancer immune response. The aim of this study was to assess the clinical significance of APM components in esophageal cancer. A total of 11 esophageal cancer cell lines were evaluated by Western blot analysis for 13 HLA class I APM components. There was a different expression pattern among cancer cell lines for HLA class I heavy chain (HLA-HC), β2 microglobulin, Tapasin, TAP-1, TAP-2, LMP-7 and LMP-10. Immunohistochemical staining utilizing a tissue microarray method for HLA class I APM expression showing different expression patterns among cell lines was performed for 95 surgical specimens from patients with esophageal cancer. Prognostic factors were the down-regulation of HLA-HC, and the up-regulation of β2 microglobulin and TAP-1 in the cancer tissues. Multivariate analysis using a Cox regression model indicated that the down-regulation of HLA-HC, and up-regulation of TAP-1 in cancer tissues are independent, unfavorable prognostic factors (hazard ratio, 2.361 and 2.297; P=0.0141 and 0.0145, respectively). Although there was no significant difference in survival for selected p-stage I and II patients (n=54) in all APM components, only down-regulation of HLA-HC was an unfavorable prognostic factor by a Cox regression model for selected p-stage III and IV patients (n=41). In conclusion, the current results suggest that the down-regulation of HLA-HC in tumors is especially associated with a poor prognosis among advanced esophageal cancer patients.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1019-6439
関連情報	PMID 22134332
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/ijo.2011.1274