早期舌扁平上皮癌における頸部リンパ節後発転移・局所再発に関連する因子の臨床病理学的検討

舌扁平上皮癌

There are 81 cases, including 10 cases of local recurrence, and 20 cases of secondary metastases to cervical lymph nodes. Between recurrence cases and non-recurrence cases, p53,Ki-67,ALDH1 in the mucosal epithelium of the resection, the significant difference with the recurrence were not found, but showed a recurrence and significant correlation to degree of the cellular atypia and pattern of manifestation of podoplanin counts. Many cases of podoplanin counts showed significant correlation that a tumor showed infiltrative growth, but the case that caused secondary metastases to cervical lymph nodes did not show the tumor degree of differentiation, p53, Ki-67,ALDH1. As for the findings, the risk of the postoperative recurrence increasing in the case that cancer stem cells revealed manifestation of podoplanin that it was reported to develop to atypical epithelium cells for a recurrence, the of the tumor showed what the increase of podoplanin positive cells was associated with as well as the invasion activity of tumor cells, and it being with an index of one that it judged the prognoses such as a recurrence or the metastasis to determine manifestation of podoplanin as well as a search of the conventional histopathology immunohistologically was thought about.