Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis

Kubota, Koji; Hayama, Keiichi; Iwamoto, Hiroaki et al.

Angewandte chemie international edition, 2015, 54(30), 8809-8813

Permalink : https://hdl.handle.net/2115/62248

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アクセス権	open access
URI	https://hdl.handle.net/2115/62248
タイトル	Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis
著者	Kubota, Koji ; Hayama, Keiichi ; Iwamoto, Hiroaki ; Ito, Hajime
著者名 Kubota, Koji
著者名 Hayama, Keiichi
著者名 Iwamoto, Hiroaki
e-Rad_Researcher 90282300 著者名 Ito, Hajime
言語	英語
キーワード	borylation
	copper
	dearomatization
	enantioselective synthesis
	indoles
発行日	2015-06-20
出版者	Wiley-Blackwell
収録物名	Angewandte chemie international edition
巻(号)	54(30)
ページ	8809-8813
抄録	The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio- and enantioselective addition of active borylcopper(I) species to indole-2-carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the accepted version of the following article: Angewandte Chemie International Edition July 20, 2015, 54(30), pp.8809-8813, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201502964/abstract.
PISSN	1433-7851
関連情報	PMID 26095335
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/anie.201502964