Evaluation of the relative biological effectiveness of spot-scanning proton irradiationin vitro

Maeda, Kenichiro; Yasui, Hironobu; Matsuura, Taeko et al.

Journal of Radiation Research, 2016, 57(3), 307-311

Permalink : https://hdl.handle.net/2115/62285

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アクセス権
open access
URI
https://hdl.handle.net/2115/62285
タイトル
Evaluation of the relative biological effectiveness of spot-scanning proton irradiationin vitro
著者
Maeda, Kenichiro ; Yasui, Hironobu ; Matsuura, Taeko ; Yamamori, Tohru ; Suzuki, Motofumi ; Nagane, Masaki ; Nam, Jin-Min ; Inanami, Osamu ; Shirato, Hiroki
著者名
Maeda, Kenichiro
e-Rad_Researcher
10570228
著者名
Yasui, Hironobu
e-Rad_Researcher
90590266
著者名
Matsuura, Taeko
e-Rad_Researcher
00512675
著者名
Yamamori, Tohru
著者名
Suzuki, Motofumi
著者名
Nagane, Masaki
著者名
Nam, Jin-Min
e-Rad_Researcher
10193559
著者名
Inanami, Osamu
e-Rad_Researcher
20187537
著者名
Shirato, Hiroki
言語
英語
キーワード
relative biological effectiveness
spot scanning
radiotherapy
proton therapy
発行日
2016-06
出版者
Oxford University Press
収録物名
Journal of Radiation Research
巻(号)
57(3)
ページ
307-311
抄録
Variations in relative biological effectiveness (RBE) from a fixed value of 1.1 are critical in proton beam therapy. To date, studies estimating RBE at multiple positions relative to the spread-out Bragg peak (SOBP) have been predominantly performed using passive scattering methods, and limited data are available for spot-scanning beams. Thus, to investigate the RBE of spot-scanning beams, Chinese hamster fibroblast V79 cells were irradiated using the beam line at the Hokkaido University Hospital Proton Therapy Center. Cells were placed at six different depths, including the entrance of the proton beam and the proximal and distal part of the SOBP. Surviving cell fractions were analyzed using colony formation assay, and cell survival curves were obtained by the curve fitted using a linear-quadratic model. RBE10 and RBE37 were 1.15 and 1.21 at the center of the SOBP, respectively. In contrast, the distal region showed higher RBE values (1.50 for RBE10 and 1.85 for RBE37). These results are in line with those of previous studies conducted using passive scattering proton beams. Taken together, these data strongly suggest that variations in RBE should be considered during treatment planning for spot-scanning beams as well as for passive scattering proton beams.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial 4.0 International
PISSN
0449-3060
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1093/jrr/rrv101