Comparison of acute toxicities associated with cetuximab-based bioradiotherapy and platinum-based chemoradiotherapy for head and neck squamous cell carcinomas : A single-institution retrospective study in Japan

Sakashita, Tomohiro; Homma, Akihiro; Hatakeyama, Hiromitsu; Furusawa, Jun; Kano, Satoshi; Mizumachi, Takatsugu; Iizuka, Satoshi; Onimaru, Rikiya; Tsuchiya, Kazuhiko; Yasuda, Koichi; Shirato, Hiroki; Fukuda, Satoshi

Comparison of acute toxicities associated with cetuximab-based bioradiotherapy and platinum-based chemoradiotherapy for head and neck squamous cell carcinomas : A single-institution retrospective study in Japan

Sakashita, Tomohiro; Homma, Akihiro; Hatakeyama, Hiromitsu et al.

Acta Oto-laryngologica, 2015, 135(8), 853-858

Permalink : https://hdl.handle.net/2115/62577

このアイテムのアクセス数:922件（2026-10-12 15:24 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
manuscript	pdf	831 KB	1,089

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/62577
タイトル	Comparison of acute toxicities associated with cetuximab-based bioradiotherapy and platinum-based chemoradiotherapy for head and neck squamous cell carcinomas : A single-institution retrospective study in Japan
著者	Sakashita, Tomohiro ; Homma, Akihiro ; Hatakeyama, Hiromitsu ; Furusawa, Jun ; Kano, Satoshi ; Mizumachi, Takatsugu ; Iizuka, Satoshi ; Onimaru, Rikiya ; Tsuchiya, Kazuhiko ; Yasuda, Koichi ; Shirato, Hiroki ; Fukuda, Satoshi
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
著者名 Furusawa, Jun
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
e-Rad_Researcher 00507577 著者名 Mizumachi, Takatsugu
著者名 Iizuka, Satoshi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 60580892 著者名 Tsuchiya, Kazuhiko
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
キーワード	mucositis
	dermatitis
	cisplatin
	radiotherapy
	chemotherapy
	molecular target therapy
発行日	2015-08
出版者	Taylor & Francis
収録物名	Acta Oto-laryngologica
巻(号)	135(8)
ページ	853-858
抄録	Conclusion: Grade ≥ 3 mucositis/stomatitis and inability to feed orally were problematic for patients undergoing cetuximab-based bioradiotherapy (BRT) as well as platinum-based chemoradiotherapy (CRT). Severe mucositis/stomatitis and radiation dermatitis should be addressed carefully in patients undergoing cetuximab-based BRT as well. Objectives: The efficacy of cetuximab-based BRT in locally advanced head and neck squamous cell carcinomas has been established. However, the safety of cetuximab-based BRT in comparison with platinum-based CRT is currently under investigation. Method: This study retrospectively analyzed 14 patients undergoing cetuximab-based BRT and 29 patients undergoing platinum-based CRT to compare the incidence of acute toxicities. In the BRT group, an initial cetuximab loading dose of 400 mg/m2 was delivered 1 week before the start of radiotherapy. Seven weekly infusions of 250 mg/m2 of cetuximab followed during the definitive radiotherapy. In the CRT group, cisplatin was administered at a dose of 40 mg/m2 weekly during the definitive radiotherapy. Results: The BRT group had a higher incidence of Grade ≥ 3 radiation dermatitis than did the CRT group (43% vs 3%, respectively, p < 0.01). The incidence rate of Grade ≥ 3 mucositis/stomatitis was 64.3% and 41.4% in the BRT and CRT group, respectively (p = 0.1484), while the incidence rate of the inability to feed orally was 38.5% and 55.2%, respectively (p = 0.2053).
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica on 2015, available online: http://www.tandfonline.com/10.3109/00016489.2015.1030772
PISSN	0001-6489
EISSN	1651-2251
NCID	AA0050923X
関連情報	PMID 25814008
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.3109/00016489.2015.1030772