The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

Sato, Seiichi; Li, Kai; Kameyama, Takeshi; Hayashi, Takaya; Ishida, Yuji; Murakami, Shuko; Watanabe, Tsunamasa; Iijima, Sayuki; Sakurai, Yu; Watashi, Koichi; Tsutsumi, Susumu; Sato, Yusuke; Akita, Hidetaka; Wakita, Takaji; Rice, Charles M.; Harashima, Hideyoshi; Kohara, Michinori; Tanaka, Yasuhito; Takaoka, Akinori

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

Sato, Seiichi; Li, Kai; Kameyama, Takeshi et al.

Immunity, 2015, 42(1), 123-132

Permalink : https://hdl.handle.net/2115/62620

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アクセス権	open access
URI	https://hdl.handle.net/2115/62620
タイトル	The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
その他のタイトル	RIG-I functions as a dual effector against HBV
著者	Sato, Seiichi ; Li, Kai ; Kameyama, Takeshi ; Hayashi, Takaya ; Ishida, Yuji ; Murakami, Shuko ; Watanabe, Tsunamasa ; Iijima, Sayuki ; Sakurai, Yu ; Watashi, Koichi ; Tsutsumi, Susumu ; Sato, Yusuke ; Akita, Hidetaka ; Wakita, Takaji ; Rice, Charles M. ; Harashima, Hideyoshi ; Kohara, Michinori ; Tanaka, Yasuhito ; Takaoka, Akinori
著者名 Sato, Seiichi
著者名 Li, Kai
e-Rad_Researcher 40569505 著者名 Kameyama, Takeshi
著者名 Hayashi, Takaya
著者名 Ishida, Yuji
e-Rad_Researcher 50454848 著者名 Murakami, Shuko
e-Rad_Researcher 20338528 著者名 Watanabe, Tsunamasa
e-Rad_Researcher 00416273 著者名 Iijima, Sayuki
著者名 Sakurai, Yu
e-Rad_Researcher 40378948 著者名 Watashi, Koichi
著者名 Tsutsumi, Susumu
e-Rad_Researcher 10735624 著者名 Sato, Yusuke
e-Rad_Researcher 80344472 著者名 Akita, Hidetaka
e-Rad_Researcher 40280789 著者名 Wakita, Takaji
著者名 Rice, Charles M.
e-Rad_Researcher 00183567 著者名 Harashima, Hideyoshi
e-Rad_Researcher 10250218 著者名 Kohara, Michinori
e-Rad_Researcher 90336694 著者名 Tanaka, Yasuhito
e-Rad_Researcher 30323611 著者名 Takaoka, Akinori
言語	英語
発行日	2015-01-20
出版者	Cell Press
収録物名	Immunity
巻(号)	42(1)
ページ	123-132
記述	Supplemental materials are available on the publisher's website.
抄録	Host innate recognition triggers key immune responses for viral elimination. The sensing mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream signaling events remain to be fully clarified. Here we found that type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (RIG-I)-mediated sensing of the 5'-ε region of HBV pregenomic RNA. In addition, RIG-I could also counteract the interaction of HBV polymerase (P protein) with the 5'-ε region in an RNA-binding dependent manner, which consistently suppressed viral replication. Liposome-mediated delivery and vector-based expression of this ε region-derived RNA in liver abolished the HBV replication in human hepatocyte-chimeric mice. These findings identify an innate recognition mechanism by which RIG-I dually functions as an HBV sensor activating innate signaling and to counteract viral polymerase in human hepatocytes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1074-7613
関連情報	PMID 25557055
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.immuni.2014.12.016