CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

Kubo, Kaori; Iwakami, Masashi; Muromoto, Ryuta; Inagaki, Takuya; Kitai, Yuichi; Kon, Shigeyuki; Sekine, Yuichi; Oritani, Kenji; Matsuda, Tadashi

CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

Kubo, Kaori; Iwakami, Masashi; Muromoto, Ryuta et al.

Biochemical and biophysical research communications, 2015, 463(4), 825-831

Permalink : https://hdl.handle.net/2115/62630

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アクセス権	open access
URI	https://hdl.handle.net/2115/62630
タイトル	CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells
著者	Kubo, Kaori ; Iwakami, Masashi ; Muromoto, Ryuta ; Inagaki, Takuya ; Kitai, Yuichi ; Kon, Shigeyuki ; Sekine, Yuichi ; Oritani, Kenji ; Matsuda, Tadashi
著者名 Kubo, Kaori
著者名 Iwakami, Masashi
著者名 Muromoto, Ryuta
著者名 Inagaki, Takuya
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
e-Rad_Researcher 90344499 著者名 Kon, Shigeyuki
e-Rad_Researcher 20396295 著者名 Sekine, Yuichi
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	CML
	BCR-ABL
	STAP-2
	CCR7
	MAPK/ERK
発行日	2015-08-07
出版者	Elsevier
収録物名	Biochemical and biophysical research communications
巻(号)	463(4)
ページ	825-831
抄録	Chronic myeloid leukemia is a clonal disease characterized by the presence of the Philadelphia chromosome and its oncogenic product, BCR-ABL, which activates multiple pathways involved in cell survival, growth promotion, and disease progression. We previously reported that in murine hematopoietic Ba/F3 cells, signal transducing adaptor protein-2 (STAP-2) binds to BCR-ABL and up-regulates BCR-ABL phosphorylation, leading to enhanced activation of its downstream signaling molecules. The binding of STAP2 to BCR-ABL also influenced the expression levels of chemokine receptors, such as CXCR4 and CCR7. For the induction of CCR7 expression, signals mediated by the MAPK/ERK pathway were critical in Ba/F3 cells expressing BCR-ABL and STAP-2. In addition, STAP-2 cooperated with BCR-ABL to induce the production of CCR7 ligands, CCL19 and CCL21. Our results demonstrate a contribution of CCR7 to STAP-2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells. (C) 2015 Elsevier Inc. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0006-291X
関連情報	PMID 26102025
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2015.06.020