Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog

Momose, Takehito; Miyaji, Hirofumi; Kato, Akihito; Ogawa, Kosuke; Yoshida, Takashi; Nishida, Erika; Murakami, Syusuke; Kosen, Yuta; Sugaya, Tsutomu; Kawanami, Masamitsu

Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog

Momose, Takehito; Miyaji, Hirofumi; Kato, Akihito et al.

The Open Dentistry Journal, 2016, 10(1), 347-359

Permalink : https://hdl.handle.net/2115/62682

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アクセス権	open access
URI	https://hdl.handle.net/2115/62682
タイトル	Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog
著者	Momose, Takehito ; Miyaji, Hirofumi ; Kato, Akihito ; Ogawa, Kosuke ; Yoshida, Takashi ; Nishida, Erika ; Murakami, Syusuke ; Kosen, Yuta ; Sugaya, Tsutomu ; Kawanami, Masamitsu
著者名 Momose, Takehito
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
e-Rad_Researcher 40507571 著者名 Kato, Akihito
著者名 Ogawa, Kosuke
著者名 Yoshida, Takashi
著者名 Nishida, Erika
著者名 Murakami, Syusuke
著者名 Kosen, Yuta
e-Rad_Researcher 10211301 著者名 Sugaya, Tsutomu
e-Rad_Researcher 10133761 著者名 Kawanami, Masamitsu
言語	英語
キーワード	Alveolar Bone Regeneration
	Biomaterial
	Periodontal Attachment
	Periodontal Tissue Engineering
発行日	2016
出版者	Bentham Open
収録物名	The Open Dentistry Journal
巻(号)	10(1)
ページ	347-359
抄録	Objective: Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation defects in beagle dogs. Methods: Collagen hydrogel was fabricated from bovine type I collagen with an ascorbate-copper ion cross-linking system. Collagen hydrogel was mingled with FGF2 and injected into sponge-form collagen. Subsequently, FGF2 (50 μg)/collagen hydrogel scaffold and collagen hydrogel scaffold alone were implanted into class II furcation defects in dogs. In addition, no implantation was performed as a control. Histometric parameters were assessed at 10 days and 4 weeks after surgery. Result: FGF2 application to scaffold promoted considerable cell and tissue ingrowth containing numerous cells and blood vessel-like structure at day 10. At 4 weeks, reconstruction of alveolar bone was stimulated by implantation of scaffold loaded with FGF2. Furthermore, periodontal attachment, consisting of cementum-like tissue, periodontal ligament-like tissue and Sharpey’s fibers, was also repaired, indicating that FGF2-loaded scaffold guided self-assembly and then re-established the function of periodontal organs. Aberrant healing, such as ankylosis and root resorption, was not observed. Conclusion: FGF2-loaded collagen hydrogel scaffold possessed excellent biocompatibility and strongly promoted periodontal tissue engineering, including periodontal attachment re-organization.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	1874-2106
関連情報	URI http://benthamopen.com/todentj/home
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2174/1874210601610010347