Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice : a prospective cohort studya prospective cohort study

Kubo, Kimitoshi; Kawakami, Hiroshi; Kuwatani, Masaki et al.

BMC gastroenterology, 2016, 16, 65

Permalink : https://hdl.handle.net/2115/62690

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アクセス権
open access
URI
https://hdl.handle.net/2115/62690
タイトル
Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice : a prospective cohort studya prospective cohort study
著者
Kubo, Kimitoshi ; Kawakami, Hiroshi ; Kuwatani, Masaki ; Nishida, Mutsumi ; Kawakubo, Kazumichi ; Kawahata, Shuhei ; Taya, Yoko ; Kubota, Yoshimasa ; Amano, Toraji ; Shirato, Hiroki ; Sakamoto, Naoya
著者名
Kubo, Kimitoshi
e-Rad_Researcher
80399823
著者名
Kawakami, Hiroshi
e-Rad_Researcher
50431375
著者名
Kuwatani, Masaki
e-Rad_Researcher
90404722
著者名
Nishida, Mutsumi
著者名
Kawakubo, Kazumichi
著者名
Kawahata, Shuhei
著者名
Taya, Yoko
著者名
Kubota, Yoshimasa
著者名
Amano, Toraji
e-Rad_Researcher
20187537
著者名
Shirato, Hiroki
e-Rad_Researcher
10334418
著者名
Sakamoto, Naoya
言語
英語
キーワード
Liver Elasticity
Obstructive jaundice
Biliary drainage
Transient elastography
Virtual Touch (TM) Quantification
Liver fibrosis
Hyaluronic acid
Procollagen-III-peptide
発行日
2016-07-08
出版者
BioMed Central
収録物名
BMC gastroenterology
巻(号)
16
ページ
65
抄録
Background: Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. Methods: This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elastography (TE) and Virtual Touch (TM) Quantification (VTQ). Serum total bilirubin (T-Bil) level was measured before biliary drainage (Day 0), with measures repeated at 2 days (Day 2) and 7 days (Day 7) after biliary drainage. Serum levels of the following markers of liver fibrosis were also obtained on Day 0 and Day 7: hyaluronic acid (HA), procollagen-III-peptide (P-III-P). Results: T-Bil, TE, and VTQ for the left (VTQ-L) and right (VTQ-R) lobes of the liver were all elevated before biliary drainage, with respective levels, measured at Day 0, of 11.9 +/- 1.5 mg/dl, 12.1 +/- 0.9 kPa, 2.23 +/- 0.10 m/s, and 1.85 +/- 0. 10 m/s. All values decreased on Day 7 after drainage: T-Bil, 4.7 +/- 1.0 mg/dl (P < 0.001); TE, 7.6 +/- 0.6 kPa (P < 0.001); VTQ-L, 1.53 +/- 0.08 m/s (P < 0.001); and VTQ-R, 1.30 +/- 0.05 m/s (P < 0.001). Similar changes were observed in serum markers of liver fibrosis. Liver elasticity measures correlated with serum levels of T-Bil, P-III-P, and HA (r = 0.35-0.67, P < 0.001). Conclusions: This study confirmed decreases in liver elasticity, measured by TE and VTQ, after biliary drainage. Measures of liver elasticity correlated to levels of T-Bil and serum markers of liver fibrosis. (UMIN ID: UMIN00001284313).
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1471-230X
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s12876-016-0479-3