open access

https://hdl.handle.net/2115/62695

Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E

英語

Alzheimer's disease

2015

Wiley

FEBS Letters

589(18)

2394-2400

Intracellular metabolism of amyloid beta-protein precursor (APP) is important for the pathogenesis of Alzheimer's disease (AD). Alcadeins (Alc alpha, Alc beta, and Alc gamma) are neural membrane proteins similar to APP in their localization, metabolism, and cellular function. Isoform epsilon 4 of apolipoprotein E (ApoE) is a major risk factor for AD. We found that ApoE expression attenuated intracellular trafficking of APP and Alc beta, resulting in metabolic stabilization of both proteins. By contrast, Alc alpha intracellular proteolysis was facilitated by ApoE expression, which was not due to an increase in the primary cleavage of Alc alpha. This difference may result from binding of ApoE to membrane proteins.

学術雑誌論文

Accepted Manuscript

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

This is the peer reviewed version of the following article: Kimura Ayano, Hata Saori and Suzuki Toshiharu(2015), Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E, FEBS Letters, 589, which has been published in final form at http://dx.doi.org/10.1016/j.febslet.2015.07.017. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

0014-5793