Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro

Endo, Shogo; Kudo, Nobuki; Yamaguchi, Shigeru; Sumiyoshi, Koki; Motegi, Hiroaki; Kobayashi, Hiroyuki; Terasaka, Shunsuke; Houkin, Kiyohiro

Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro

Endo, Shogo; Kudo, Nobuki; Yamaguchi, Shigeru et al.

Ultrasound in medicine and biology, 2015, 41(9), 2458-2465

Permalink : https://hdl.handle.net/2115/62735

このアイテムのアクセス数:1,201件（2026-08-08 19:29 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
manuscript	pdf	2.92 MB	1,305

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/62735
タイトル	Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro
著者	Endo, Shogo ; Kudo, Nobuki ; Yamaguchi, Shigeru ; Sumiyoshi, Koki ; Motegi, Hiroaki ; Kobayashi, Hiroyuki ; Terasaka, Shunsuke ; Houkin, Kiyohiro
著者名 Endo, Shogo
e-Rad_Researcher 30271638 著者名 Kudo, Nobuki
著者名 Yamaguchi, Shigeru
著者名 Sumiyoshi, Koki
著者名 Motegi, Hiroaki
著者名 Kobayashi, Hiroyuki
e-Rad_Researcher 10447055 著者名 Terasaka, Shunsuke
e-Rad_Researcher 90229146 著者名 Houkin, Kiyohiro
言語	英語
キーワード	5-Aminolevulinic acid
	In vitro
	Malignant glioma
	Porphyrin derivatives
	Protoporphyrin IX
	Sonodynamic therapy
	Talaporfin sodium
	Ultrasound
発行日	2015-09
出版者	Elsevier
収録物名	Ultrasound in medicine and biology
巻(号)	41(9)
ページ	2458-2465
抄録	Because it is highly infiltrative, malignant glioma is a cancer with a poor prognosis despite multidisciplinary treatment strategies, such as aggressive surgery and chemoradiotherapy, necessitating new therapeutic approaches to control migration of tumor cells. In our study, we investigated the efficacy of sonodynamic therapy of glioma cells in vitro using porphyrin derivatives, including 5-aminolevulinic acid, protoporphyrin IX and talaporfin sodium, as sonosensitizers. These substances have been known to accumulate in glioma cells and are expected to have cytotoxic effects on sonication. Our study found that the cytotoxicity of sonication of glioma cells is enhanced by each sonosensitizer and that the efficacy of sonodynamic therapy may depend on the degree of intracellular accumulation of sonosensitizer. Also, the study suggests that induction of apoptosis is a major mechanism underlying cell death. Though further investigations are necessary, our preliminary result indicates a potential for sonodynamic therapy with sonosensitizers in glioma treatment.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0301-5629
NCID	AA00876354
関連情報	PMID 26071619
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ultrasmedbio.2015.05.007