MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease

Otani, Yuki; Ichii, Osamu; Otsuka-Kanazawa, Saori; Chihara, Masataka; Nakamura, Teppei; Kon, Yasuhiro

MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease

Otani, Yuki; Ichii, Osamu; Otsuka-Kanazawa, Saori et al.

Autoimmunity, 2015, 48(6), 402-411

Permalink : https://hdl.handle.net/2115/62751

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アクセス権	open access
URI	https://hdl.handle.net/2115/62751
タイトル	MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease
著者	Otani, Yuki ; Ichii, Osamu ; Otsuka-Kanazawa, Saori ; Chihara, Masataka ; Nakamura, Teppei ; Kon, Yasuhiro
著者名 Otani, Yuki
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 10566152 著者名 Otsuka-Kanazawa, Saori
著者名 Chihara, Masataka
著者名 Nakamura, Teppei
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	MRL/lpr mice
	autoimmune disease
	ovary
	estrous cycle
	ovarian reserve
発行日	2015-09
出版者	Taylor & Francis
収録物名	Autoimmunity
巻(号)	48(6)
ページ	402-411
抄録	The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmune disease-prone MRL/MpJ (MRL/+) mice and congenic MRL/MpJ-Fas(lpr) (MRL/lpr) mice harboring a mutation in the Fas gene that speeds disease onset. Both MRL-background strains showed earlier vaginal opening than C57BL/6 mice. The estrous cycle became irregular by 6 and 12 months of age in MRL/lpr mice and mice of the other two strains, respectively. Histological analysis at 3 months revealed that the number of primordial follicles was smaller in MRL-background mice than in C57BL/6 mice after 3 months. In addition, MRL/lpr and MRL/+ mice displayed lower numbers of ovarian follicles and corpora lutea at 3 and 6 months, and 6 and 12 months, respectively, than that in age-matched C57BL/6 mice. MRL/lpr and MRL/+ mice developed ovarian interstitial glands after 3 and 6 months, respectively. In particular, MRL/lpr mice showed numerous infiltrating lymphocytes within the ovarian interstitia, and partially stratified ovarian surface epithelia with more developed microvilli than that observed in C57BL/6 mice at 6 months. No significant differences in serum hormone levels were observed between the strains. In conclusion, MRL/lpr mice display altered ovarian development, morphology and function consistent with the progression of severe autoimmune disease, as these findings are less severe in MRL/+ counterparts.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is an Accepted Manuscript of an article published by Taylor & Francis in 'Autoimmunity' on 2015-08-27, available online: http://www.tandfonline.com/10.3109/08916934.2015.1031889
PISSN	0891-6934
NCID	AA10707648
関連情報	PMID 25857350
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.3109/08916934.2015.1031889