Effects of prehospital epinephrine administration on neurological outcomes in patients with out-of-hospital cardiac arrest

Ono, Yuichi; Hayakawa, Mineji; Wada, Takeshi; Sawamura, Atsushi; Gando, Satoshi

Effects of prehospital epinephrine administration on neurological outcomes in patients with out-of-hospital cardiac arrest

Ono, Yuichi; Hayakawa, Mineji; Wada, Takeshi et al.

Journal of Intensive Care, 2015, 3, 29

Permalink : https://hdl.handle.net/2115/62779

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アクセス権	open access
URI	https://hdl.handle.net/2115/62779
タイトル	Effects of prehospital epinephrine administration on neurological outcomes in patients with out-of-hospital cardiac arrest
著者	Ono, Yuichi ; Hayakawa, Mineji ; Wada, Takeshi ; Sawamura, Atsushi ; Gando, Satoshi
著者名 Ono, Yuichi
e-Rad_Researcher 10374282 著者名 Hayakawa, Mineji
e-Rad_Researcher 30455646 著者名 Wada, Takeshi
e-Rad_Researcher 00241448 著者名 Sawamura, Atsushi
e-Rad_Researcher 30125306 著者名 Gando, Satoshi
言語	英語
キーワード	Out-of-hospital cardiac arrest
	Resuscitation
	Epinephrine
	Prehospital
発行日	2015-06-24
出版者	BioMed Central
収録物名	Journal of Intensive Care
巻(号)	3
ページ	29
抄録	Background: To determine if the effects of epinephrine administration on the outcome of out-of-hospital cardiac arrest (OHCA), patients are associated with the duration of cardiopulmonary resuscitation (CPR) performed by Emergency Medical Service (EMS) personnel. Methods: This retrospective, nonrandomized, observational analysis used the All-Japan Utstein Registry, a prospective, nationwide population-based registry of all OHCA patients transported to the hospital by EMS staff as the data source. We stratified all OHCA patients for quartile of EMSs' CPR duration. Group 1 consisted of patients who fell under the 25th percentile of EMSs' CPR duration (under 15 min); group 2, patients who fell into the 25th to 50th percentile (between 15 and 19 min); group 3, patients who fell into the 50th to 75th percentile (between 20 and 26 min); and group 4, patients who fell at or above the 75th percentile (over 26 min). The primary endpoint was a favorable neurological outcome 1 month after cardiac arrest. The secondary endpoints were ROSC before arrival at the hospital and 1-month survival. Results: A total of 383,811 patients aged over 18 years who had experienced OHCA between 2006 and 2010 in Japan, when stratified for quartile of EMSs' CPR duration, the epinephrine administration increased the rate of return of spontaneous circulation (ROSC) approximately tenfold in all groups. However, the beneficial effects of epinephrine administration on 1-month survival disappeared in patients on whom EMSs' CPR had been performed for more than 26 min, and the beneficial effects of epinephrine administration on neurological outcomes were observed only in patients on whom EMSs' CPR had been performed between 15 and 19 min (odds ratio, 1.327, 95 % confidence intervals, 1.017-1.733 P = 0.037). Conclusions: Epinephrine administration is associated with an increase of ROSC and with improvement in the neurological outcome on which EMSs' CPR duration is performed between 15 and 19 min.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	2052-0492
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s40560-015-0094-3