The Potential Role of Macrophage Migration Inhibitory Factor on the Migration of Vascular Smooth Muscle Cells

Okamoto, Toshiya; Atsumi, Toshiya; Shimizu, Chikara; Yoshioka, Narihito; Koike, Takao

The Potential Role of Macrophage Migration Inhibitory Factor on the Migration of Vascular Smooth Muscle Cells

Okamoto, Toshiya; Atsumi, Toshiya; Shimizu, Chikara et al.

Journal of Atherosclerosis and Thrombosis, 2008, 15(1), 13-19

Permalink : https://hdl.handle.net/2115/62835

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アクセス権	open access
URI	https://hdl.handle.net/2115/62835
タイトル	The Potential Role of Macrophage Migration Inhibitory Factor on the Migration of Vascular Smooth Muscle Cells
著者	Okamoto, Toshiya ; Atsumi, Toshiya ; Shimizu, Chikara ; Yoshioka, Narihito ; Koike, Takao
著者名 Okamoto, Toshiya
e-Rad_Researcher 90359480 著者名 Atsumi, Toshiya
e-Rad_Researcher 00292029 著者名 Shimizu, Chikara
e-Rad_Researcher 20200941 著者名 Yoshioka, Narihito
e-Rad_Researcher 80146795 著者名 Koike, Takao
言語	英語
キーワード	MIF
	Vascular smooth muscle cells
	Migration
	Atherosclerosis
発行日	2008-03
出版者	Japan Atherosclerosis Society
収録物名	Journal of Atherosclerosis and Thrombosis
巻(号)	15(1)
ページ	13-19
記述	This is an open access article distributed under the Creative Commons Attribution-NonCommercial-ShareAlike license.
抄録	Aim: Macrophage migration inhibitory factor (MIF) is known as a pro-inflammatory cytokine that regulates a broad spectrum of inflammatory reactions. MIF is expressed in vascular smooth muscle cells (VSMCs), and inhibition of the progression of atherosclerosis was observed in MIF-deficient atherosclerotic mice. However, the functional role of MIF in VSMCs has not been elucidated. The aim of this study was to investigate the role of MIF on the migration of VSMCs. Methods: Cultured rat A10 cells, derived from rat embryonic aortic smooth muscle cells, were stimulated with oxLDL, and the effect of MIF knockdown on oxLDL-mediated migration of A10 cells was analyzed. Results: Intracellular MIF content was significantly increased and a marked increase of MIF concent-ration was observed in the supernatant of A10 cells treated with oxLDL. The migration of A10 cells was significantly accelerated by the stimulation of recombinant MIF in a dose-dependent manner. Notably, knockdown of intracellular MIF by siRNA abolished oxLDL-induced migration of A10 cells. Conclusion: These findings suggest that MIF acts on the migration of VSMCs in an autocrine and paracrine fashion. MIF appears to be a novel target for the prevention of cardiovascular events.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1880-3873
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.5551/jat.E495