open access

https://hdl.handle.net/2115/62917

TRIM29 regulates the p63-mediated pathway in cervical cancer cells

英語

Integrin

2015-10

Elsevier

Biochimica et Biophysica Acta. Molecular Cell Research

1853(10A)

2296-2305

Cell invasion and adhesion play an important role in cancer metastasis and are orchestrated by a complicated network of transcription factors including p63. Here, we show that a member of the tripartite motif protein family, TRIM29, is required for regulation of the p63-mediated pathway in cervical cancer cells. TRIM29 knockdown alters the adhesion and invasion activities of cervical cancer cells. TRIM29 knockdown and overexpression cause a significant decrease and increase of TAp63 alpha expression, respectively. TRIM29 knockdown alters the expression pattern of integrins and increases ZEB1 expression. TRIM29 is required for suppression of an increase in the adhesion activity of cells by TAp63 alpha. These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells.

学術雑誌論文

Accepted Manuscript

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

0167-4889