The dynamics of mucosal-associated invariant T cells in multiple sclerosis

Sugimoto, Chie; Hirotani, Makoto; Yoshikiyo, Kazunori et al.

Springerplus, 2016, 5, 1259

Permalink : https://hdl.handle.net/2115/62979

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/62979
タイトル
The dynamics of mucosal-associated invariant T cells in multiple sclerosis
著者
Sugimoto, Chie ; Hirotani, Makoto ; Yoshikiyo, Kazunori ; Koshimizu, Uichi ; Wakao, Rika ; Horinouchi, Takahiro ; Mazaki, Yuichi ; Higashi, Tsunehiko ; Fukazawa, Toshiyuki ; Fujita, Hiroyoshi ; Sasaki, Hidenao ; Wakao, Hiroshi
著者名
Sugimoto, Chie
e-Rad_Researcher
60399920
著者名
Hirotani, Makoto
著者名
Yoshikiyo, Kazunori
著者名
Koshimizu, Uichi
著者名
Wakao, Rika
e-Rad_Researcher
20307771
著者名
Horinouchi, Takahiro
著者名
Mazaki, Yuichi
著者名
Higashi, Tsunehiko
著者名
Fukazawa, Toshiyuki
e-Rad_Researcher
60142931
著者名
Fujita, Hiroyoshi
e-Rad_Researcher
80281806
著者名
Sasaki, Hidenao
e-Rad_Researcher
30360671
著者名
Wakao, Hiroshi
言語
英語
キーワード
Multiple sclerosis
Mucosal associated invariant T cells
FTY720
Disease-modifying therapy
Phenotyping
発行日
2016-08-05
出版者
Springer
収録物名
Springerplus
巻(号)
5
ページ
1259
抄録
Background: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination, gliosis and axonal loss in the Central Nervous System. Although the etiology of the disease has remained enigmatic, recent studies have suggested a role of the innate-like T cells, called Mucosal Associated Invariant T cells (MAITs) in the pathophysiology. In the present study, we have analyzed the relative frequency of MAITs and the expression of the cell surface antigens in MAITs to seek a possible link to the disease. Results: There was little difference in the frequency of total MAITs between healthy donors (HDs) and untreated MS patients, whereas the latter harbored more CD8lo/neg (DN) MAITs concomitant with a decrease in CD8high MAITs and in CD4 MAITs compared with those in HDs. While the expression of CCR5, CCR6, CD95, CD127, and CD150 has increased in untreated subjects compared with that in HDs, CD45RO has declined in untreated subjects in both DN MAITs and CD8hi MAITs. FTY720 therapy has increased the relative frequency of total MAITs in a time-dependent fashion up to 2 years. Intriguingly, FTY720 therapy for 3 years reversed the above phenotype, engendering more CD8high MAITs accompanied with decreased DN MAITs. FTY720 therapy affected the cytokine production from CD4 T cells and also enhanced the relative frequency of cells producing both TNF-α and IFN-γ from MAITs, CD8 T cells, and CD4 T cells compared with that in untreated subjects. Conclusions: FTY 720 therapy enhanced the relative frequency of MAITs in MS patients in a time-dependent manner. Although the expression of CD8 in MAITs has been affected early by FTY720, longer treatment has reversed the phenotypic change. These data demonstrated that FTY720 induced dynamic change in the relative frequency and in the phenotype of MAITs in MS.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
2193-1801
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s40064-016-2923-9