Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

Kitao, Tomoka; Hirata, Kenji; Shima, Katsumi; Hayashi, Takashi; Sekizawa, Mitsunori; Takei, Toshiki; Ichimura, Wataru; Harada, Masao; Kondo, Keishi; Tamaki, Nagara

Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

Kitao, Tomoka; Hirata, Kenji; Shima, Katsumi et al.

BMC cancer, 2016, 16, 576

Permalink : https://hdl.handle.net/2115/62983

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アクセス権	open access
URI	https://hdl.handle.net/2115/62983
タイトル	Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer
著者	Kitao, Tomoka ; Hirata, Kenji ; Shima, Katsumi ; Hayashi, Takashi ; Sekizawa, Mitsunori ; Takei, Toshiki ; Ichimura, Wataru ; Harada, Masao ; Kondo, Keishi ; Tamaki, Nagara
著者名 Kitao, Tomoka
e-Rad_Researcher 30431365 著者名 Hirata, Kenji
著者名 Shima, Katsumi
著者名 Hayashi, Takashi
著者名 Sekizawa, Mitsunori
著者名 Takei, Toshiki
著者名 Ichimura, Wataru
著者名 Harada, Masao
著者名 Kondo, Keishi
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	Lung cancer
	Reproducibility
	Metabolic tumor volume
	Total lesion glycolysis
	FDG-PET
発行日	2016-08-02
出版者	BioMed Central
収録物名	BMC cancer
巻(号)	16
ページ	576
抄録	Background: Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and inter-operator reproducibility to measure the MTV and TLG, and to estimate their dependency on the uptake time. Methods: Fifty NSCLC patients underwent preoperative FDG-PET. After an injection of FDG, the whole body was scanned twice: at the early phase (61.4 ± 2.8 min) and delayed phase (117.7 ± 1.6 min). Two operators independently defined the tumor boundary using three different delineation methods: (1) the absolute SUV threshold method (MTVp and TLGp; p = 2.0, 2.5, 3.0, 3.5), (2) the fixed% SUVmax threshold method (MTVq% and TLGq%; q = 35, 40, 45), and (3) the adaptive region-growing method (MTVARG and TLGARG). Parameters were compared between operators and between phases. Results: Both the intra- and inter-operator reproducibility were high for all parameters using any method (intra-class correlation > 0.99 each). MTV3.0 and MTV3.5 resulted in a significant increase from the early to delayed phase (P < 0.05 for both), whereas MTV2.0 and MTV2.5 neither increased nor decreased (P = n.s.). All of the MTVq% values significantly decreased over time (P < 0.01), whereas MTVARG and TLG with any delineation method increased significantly (P < 0.05). Conclusions: High reproducibility of MTV and TLG was obtained by all of the methods used. MTV2.0 and MTV2.5 were the least sensitive to uptake time, and may be good alternatives when we compare images acquired with different uptake times, although applying constant uptake time is important for volume measurement.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1471-2407
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12885-016-2624-3