Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma

Fujima, Noriyuki; Kameda, Hiroyuki; Tsukahara, Akiko; Yoshida, Daisuke; Sakashita, Tomohiro; Homma, Akihiro; Tha, Khin Khin; Kudo, Kohsuke; Shirato, Hiroki

Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma

Fujima, Noriyuki; Kameda, Hiroyuki; Tsukahara, Akiko et al.

European journal of radiology, 2015, 84(11), 2187-2193

Permalink : https://hdl.handle.net/2115/63369

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アクセス権	open access
URI	https://hdl.handle.net/2115/63369
タイトル	Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma
著者	Fujima, Noriyuki ; Kameda, Hiroyuki ; Tsukahara, Akiko ; Yoshida, Daisuke ; Sakashita, Tomohiro ; Homma, Akihiro ; Tha, Khin Khin ; Kudo, Kohsuke ; Shirato, Hiroki
e-Rad_Researcher 80431360 著者名 Fujima, Noriyuki
著者名 Kameda, Hiroyuki
著者名 Tsukahara, Akiko
著者名 Yoshida, Daisuke
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 20451445 著者名 Tha, Khin Khin
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Tumor blood flow
	Pseudo-continuous arterial spin labeling
	Squamous cell carcinoma
	Malignant lymphoma
発行日	2015-11
出版者	Elsevier
収録物名	European journal of radiology
巻(号)	84(11)
ページ	2187-2193
抄録	Objectives: To investigate the diagnostic value of tumor blood flow (TBF) obtained with pseudocontinuous arterial spin labeling (pCASL) for the differentiation of squamous cell carcinoma (SCC) and malignant lymphoma (ML) in the nasal or sinonasal cavity. Methods: Thirty-three patients with SCC and 6 patients with ML in the nasal or sinonasal cavity were retrospectively analyzed. Quantitative TBF values were obtained using whole-tumor region of interest (ROI) from pCASL data. The histogram analysis of TBF values within the tumor ROI was also performed by calculating the coefficient of variation (CV), kurtosis, and skewness. The mean TBF value, histogram CV, kurtosis and skewness of the patients with SCC were compared with those of the ML patients. The diagnostic accuracy to differentiate SCC from ML was also calculated by receiver operating characteristic (ROC) curve analysis. In addition, multiple logistic regression models were also performed to determine their independent predictive value, and diagnostic accuracy with the combined use of these parameters. Results: Between the SCC and ML groups, significant differences were observed in mean TBF, CV, and kurtosis, but not in skewness. In ROC curve analysis, the diagnostic accuracy values for the differentiation of SCC from ML in mean TBF, CV, and kurtosis were all 0.87, respectively. Multiple logistic regression models revealed TBF and CV were respectively independent predictive value. With the combination of these parameters, the diagnostic accuracy was elevated to 0.97. Conclusions: The TBF value and its histogram analysis obtained with pCASL can help differentiate SCC and ML.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0720-048X
関連情報	PMID 26277497
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ejrad.2015.07.026