A Retrospective Study of G-Tube Use in Japanese Patients Treated with Concurrent Chemoradiotherapy for Hypopharyngeal Cancer

Homma, Akihiro; Hatakeyama, Hiromitsu; Mizumachi, Takatsugu; Kano, Satoshi; Sakashita, Tomohiro; Kuramoto, Rinnosuke; Nakamaru, Yuji; Onimaru, Rikiya; Tsuchiya, Kazuhiko; Yoshida, Daisuke; Yasuda, Koichi; Shirato, Hiroki; Fukuda, Satoshi

A Retrospective Study of G-Tube Use in Japanese Patients Treated with Concurrent Chemoradiotherapy for Hypopharyngeal Cancer

Homma, Akihiro; Hatakeyama, Hiromitsu; Mizumachi, Takatsugu et al.

PLoS ONE, 2016, 11(8), e0161734

Permalink : https://hdl.handle.net/2115/63591

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アクセス権	open access
URI	https://hdl.handle.net/2115/63591
タイトル	A Retrospective Study of G-Tube Use in Japanese Patients Treated with Concurrent Chemoradiotherapy for Hypopharyngeal Cancer
著者	Homma, Akihiro ; Hatakeyama, Hiromitsu ; Mizumachi, Takatsugu ; Kano, Satoshi ; Sakashita, Tomohiro ; Kuramoto, Rinnosuke ; Nakamaru, Yuji ; Onimaru, Rikiya ; Tsuchiya, Kazuhiko ; Yoshida, Daisuke ; Yasuda, Koichi ; Shirato, Hiroki ; Fukuda, Satoshi
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
e-Rad_Researcher 00507577 著者名 Mizumachi, Takatsugu
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
著者名 Kuramoto, Rinnosuke
e-Rad_Researcher 20344509 著者名 Nakamaru, Yuji
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 60580892 著者名 Tsuchiya, Kazuhiko
著者名 Yoshida, Daisuke
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
発行日	2016-08-24
出版者	The Public Library of Science
収録物名	PLoS ONE
巻(号)	11(8)
ページ	e0161734
抄録	Objective: Late toxicity after concurrent chemoradiotherapy (CCRT), such as dysphagia, in patients with squamous cell carcinoma of the head and neck has received a good deal of attention recently. The gastrostomy tube (G-tube) dependence rate 1 year after CCRT was reported to be 16.7-42.9% in Western countries. We evaluated swallowing outcomes after CCRT in patients with hypopharyngeal cancer (HPC) treated in our hospital and compared them with previous reports. Methods: We reviewed 96 consecutive patients with a HPC treated by radiotherapy with intravenous or intra-arterial chemotherapy between 2006 and 2013 at Hokkaido University Hospital, Sapporo, Japan. Results: At 1 month after CCRT, 13 patients (13.7%) used a G-tube, whereas 5/91 (5.5%) and 4/81 (4.9%) used a G-tube at 3 and 6 months, respectively. Two patients used a G-tube at 12 and 24 months after CCRT (G-tube use rate: 2.8% at 12 months, and 3.2% at 24 months). The variables female, posterior wall primary, stage IV, ECOG performance status of 2, and smoking status were significantly associated with G-tube use at 12 months after CCRT, whereas the route of cisplatin administration was not related to G-tube use (p = 0.303). Conclusions: The G-tube use rate up to 1year could be lower in Japanese patients than in Western patients according to previous reports. In particular, Japanese patients resume oral intake sooner than Western patients. Further study of the incidence of dysphagia after CCRT by ethnicity is required to clarify the differences in dysphagia after CCRT.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0161734