Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin

Zheng, Miao; Lee, Shinhye; Tsuzuki, Satoshi; Inoue, Kazuo; Masuda, Daisaku; Yamashita, Shizuya; Iwanaga, Toshihiko

Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin

Zheng, Miao; Lee, Shinhye; Tsuzuki, Satoshi et al.

Biomedical Research, 2016, 37(4), 265-270

Permalink : https://hdl.handle.net/2115/63748

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アクセス権	open access
URI	https://hdl.handle.net/2115/63748
タイトル	Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin
著者	Zheng, Miao ; Lee, Shinhye ; Tsuzuki, Satoshi ; Inoue, Kazuo ; Masuda, Daisaku ; Yamashita, Shizuya ; Iwanaga, Toshihiko
著者名 Zheng, Miao
著者名 Lee, Shinhye
e-Rad_Researcher 50283651 著者名 Tsuzuki, Satoshi
e-Rad_Researcher 80213148 著者名 Inoue, Kazuo
e-Rad_Researcher 20568753 著者名 Masuda, Daisaku
e-Rad_Researcher 60243242 著者名 Yamashita, Shizuya
e-Rad_Researcher 10160128 著者名 Iwanaga, Toshihiko
言語	英語
発行日	2016
出版者	Biomedical Research Press
収録物名	Biomedical Research
巻(号)	37(4)
ページ	265-270
抄録	The sebaceous glands secrete sebum to protect the epidermis and hairs by the oily products. The glands express several transporters and binding proteins for the production of fatty acids and uptake of their sources. The present immunohistochemical study examined the expression and localization of CD36, MCT1, FATP4, and E-FABP in the sebaceous glands, including the meibomian and preputial glands of mice. CD36 and MCT1 in sebaceous glands were largely co-localized along the plasma membrane of secretory cells, while they were separately expressed in the glandular portion of meibomian and preputial glands. Immunoreactivities for FATP4 and E-FABP appeared diffusely in the cytoplasm of secretory cells. Genetic deletion of CD36 did not affect the immunolocalization of the three other molecules. The sebaceous glands were judged to be useful for analyzing the functions and relation of fatty acid transporters and binding proteins.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0388-6107
NCID	AA00110128
関連情報	PMID 27545003
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2220/biomedres.37.265