A characteristic of polymorphic membrane protein F of Chlamydia trachomatis isolated from male urogenital tracts in Japan

Yamazaki, Tomohiro; Matsuo, Junji; Takahashi, Satoshi; Kumagai, Shouta; Shimoda, Tomoko; Abe, Kiyotaka; Minami, Kunihiro; Yamaguchi, Hiroyuki

A characteristic of polymorphic membrane protein F of Chlamydia trachomatis isolated from male urogenital tracts in Japan

Yamazaki, Tomohiro; Matsuo, Junji; Takahashi, Satoshi et al.

Journal of Infection and Chemotherapy, 2015, 21(12), 842-848

Permalink : https://hdl.handle.net/2115/63949

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アクセス権	open access
URI	https://hdl.handle.net/2115/63949
タイトル	A characteristic of polymorphic membrane protein F of Chlamydia trachomatis isolated from male urogenital tracts in Japan
著者	Yamazaki, Tomohiro ; Matsuo, Junji ; Takahashi, Satoshi ; Kumagai, Shouta ; Shimoda, Tomoko ; Abe, Kiyotaka ; Minami, Kunihiro ; Yamaguchi, Hiroyuki
著者名 Yamazaki, Tomohiro
e-Rad_Researcher 50359486 著者名 Matsuo, Junji
著者名 Takahashi, Satoshi
著者名 Kumagai, Shouta
e-Rad_Researcher 60576180 著者名 Shimoda, Tomoko
著者名 Abe, Kiyotaka
著者名 Minami, Kunihiro
e-Rad_Researcher 40221650 著者名 Yamaguchi, Hiroyuki
言語	英語
キーワード	Chlamydia trachomatis
	Polymorphic membrane protein F (PmpF)
	Male
	Phylogenetic analysis
	Polymorphism
発行日	2015-12
出版者	日本化学療法学会・日本感染症学会
収録物名	Journal of Infection and Chemotherapy
巻(号)	21(12)
ページ	842-848
抄録	Although sexually transmitted disease due to Chlamydia trachomatis occurs similarly in both men and women, the female urogenital tract differs from that of males anatomically and physiologically, possibly leading to specific polymorphisms of the bacterial surface molecules. In the present study, we therefore characterized polymorphic features in a high-definition phylogenetic marker, polymorphic outer membrane protein (Pmp) F of C. trachomatis strains isolated from male urogenital tracts in Japan (Category: Japan-males, n = 12), when compared with those isolated from female cervical ducts in Japan (Category: Japan-females, n = 11), female cervical ducts in the other country (Category: Ref-females, n = 12) or homosexual male rectums in the other country (Category: Ref-males, n = 7), by general bioinformatics analysis tool with MAFFT software. As a result, phylogenetic reconstruction of the PmpF amino acid sequences showing three distinct clusters revealed that the Japan-males were limited into cluster 1 and 2, although there were only four clusters even though including an outgroup. Meanwhile, the phylogenetic distance values of PmpF passenger domain without hinge region, but not its full-length sequence, showed that the Japan-males were more stable and displayed less diversity when compared with the other categories, supported by the sequence conservation features. Thus, PmpF passenger domain is a useful phylogenetic maker, and the phylogenic features indicate that C. trachomatis strains isolated from male urogenital tracts in Japan may be unique, suggesting an adaptation depending on selective pressure, such as the presence or absence of microbial flora, furthermore possibly connecting to sexual differentiation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1341-321X
EISSN	1437-7780
NCID	AA11057978
関連情報	PMID 26429774
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jiac.2015.08.016