Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI

Kato, Fumi; Kudo, Kohsuke; Yamashita, Hiroko; Wang, Jeff; Hosoda, Mitsuchika; Hatanaka, Kanako C.; Mimura, Rie; Oyama-Manabe, Noriko; Shirato, Hiroki

Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI

Kato, Fumi; Kudo, Kohsuke; Yamashita, Hiroko et al.

European journal of radiology, 2016, 85(1), 96-102

Permalink : https://hdl.handle.net/2115/63971

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アクセス権	open access
URI	https://hdl.handle.net/2115/63971
タイトル	Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI
著者	Kato, Fumi ; Kudo, Kohsuke ; Yamashita, Hiroko ; Wang, Jeff ; Hosoda, Mitsuchika ; Hatanaka, Kanako C. ; Mimura, Rie ; Oyama-Manabe, Noriko ; Shirato, Hiroki
e-Rad_Researcher 80399865 著者名 Kato, Fumi
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 70332947 著者名 Yamashita, Hiroko
著者名 Wang, Jeff
e-Rad_Researcher 40443931 著者名 Hosoda, Mitsuchika
著者名 Hatanaka, Kanako C.
著者名 Mimura, Rie
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Breast cancer subtypes
	Magnetic resonance imaging
	Diffusion weighed imaging
	Ki-67
発行日	2016-01
出版者	Elsevier
収録物名	European journal of radiology
巻(号)	85(1)
ページ	96-102
抄録	Purpose: To compare the morphology and minimum apparent diffusion coefficient (ADC) values among breast cancer subtypes. Methods: Ninety-three patients, who underwent breast MRI and collectively had 98 pathologically proven invasive carcinomas, were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes. Results: Oval/round shape was significantly associated with triple-negative (TN) cancer (TN vs. non-TN: 90.9% vs. 45.2%; p = 0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p = 0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B (HER2-negative) (834 vs. 748 x 10^-6 mm2/s; p <0.025). The minimum ADC of the TN-special type was significantly higher than that of TN-ductal (997 vs. 702 x 10^-6 mm2/s; p <0.025). On the multivariate analysis comparing the characteristics associated with Luminal A vs. Luminal B (HER2-negative), the internal enhancement characteristics of the mass and minimum ADC were significant factors. Conclusion: Morphology and minimum ADC would be useful in distinguishing breast cancer subtypes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0720-048X
関連情報	PMID 26724653
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ejrad.2015.10.018