Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma

Fujima, Noriyuki; Sakashita, Tomohiro; Homma, Akihiro; Hirata, Kenji; Shiga, Tohru; Kudo, Kohsuke; Shirato, Hiroki

Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma

Fujima, Noriyuki; Sakashita, Tomohiro; Homma, Akihiro et al.

PLoS ONE, 2016, 11(11), e0166236

Permalink : https://hdl.handle.net/2115/64007

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アクセス権	open access
URI	https://hdl.handle.net/2115/64007
タイトル	Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma
著者	Fujima, Noriyuki ; Sakashita, Tomohiro ; Homma, Akihiro ; Hirata, Kenji ; Shiga, Tohru ; Kudo, Kohsuke ; Shirato, Hiroki
e-Rad_Researcher 80431360 著者名 Fujima, Noriyuki
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 30431365 著者名 Hirata, Kenji
e-Rad_Researcher 80374495 著者名 Shiga, Tohru
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
発行日	2016-11-08
出版者	The Public Library of Science
収録物名	PLoS ONE
巻(号)	11(11)
ページ	e0166236
抄録	Objective: To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). Methods: We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups). Pearson's correlation coefficients were calculated for significant correlations. Results: Significant correlations were detected: a negative correlation in the advanced T-stage group (TBF and SUV max: r, -0.61, SUVmean: r, -0.62), a positive correlation in the non-advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, 0.70, SUVmean: r, 0.73), a negative correlation in the advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, -0.62, SUVmean: r, -0.65), and a negative correlation in the advanced Tstage sinonasal cavity group (TBF and SUVmax: r, -0.61, SUVmean: r, -0.65). Conclusion: Significant correlations between glucose uptake and TBF in HNSCC were revealed by the division of T-stage and tumor location.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0166236