The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long-Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of Their Offspring : The Hokkaido Study

Kishi, Reiko; Nakajima, Tamie; Goudarzi, Houman et al.

Environmental Health Perspectives, 2015, 123(10), 1038-1045

Permalink : https://hdl.handle.net/2115/64063

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アクセス権
open access
URI
https://hdl.handle.net/2115/64063
タイトル
The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long-Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of Their Offspring : The Hokkaido Study
著者
Kishi, Reiko ; Nakajima, Tamie ; Goudarzi, Houman ; Kobayashi, Sachiko ; Sasaki, Seiko ; Okada, Emiko ; Miyashita, Chihiro ; Itoh, Sachiko ; Araki, Atsuko ; Ikeno, Tamiko ; Iwasaki, Yusuke ; Nakazawa, Hiroyuki
e-Rad_Researcher
80112449
著者名
Kishi, Reiko
著者名
Nakajima, Tamie
e-Rad_Researcher
40713607
著者名
Goudarzi, Houman
著者名
Kobayashi, Sachiko
e-Rad_Researcher
30448831
著者名
Sasaki, Seiko
e-Rad_Researcher
00766537
著者名
Okada, Emiko
e-Rad_Researcher
70632389
著者名
Miyashita, Chihiro
e-Rad_Researcher
90580936
著者名
Itoh, Sachiko
e-Rad_Researcher
00619885
著者名
Araki, Atsuko
e-Rad_Researcher
80569715
著者名
Ikeno, Tamiko
e-Rad_Researcher
10409360
著者名
Iwasaki, Yusuke
e-Rad_Researcher
50150173
著者名
Nakazawa, Hiroyuki
言語
英語
発行日
2015-10
出版者
National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services
収録物名
Environmental Health Perspectives
巻(号)
123(10)
ページ
1038-1045
抄録
Background: Fatty acids (FAs) are essential for fetal growth. Exposure to perfluorinated chemicals (PFCs) may disrupt FA homeostasis, but there are no epidemiological data regarding associations of PFCs and FA concentrations. Objectives: We estimated associations between perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) concentrations and maternal levels of FAs and triglyceride (TG) and birth size of the offspring. Methods: We analyzed 306 mother-child pairs in this birth cohort between 2002 and 2005 in Japan. The prenatal PFOS and PFOA levels were measured in maternal serum samples by liquid chromatography-tandem mass spectrometry. Maternal blood levels of nine FAs and TG were measured by gas chromatography-mass spectrometry and TG E-Test Wako kits, respectively. Information on infants' birth size was obtained from participant medical records. Results: The median PFOS and PFOA levels were 5.6 and 1.4 ng/mL, respectively. In the fully adjusted model, including maternal age, parity, annual household income, blood sampling period, alcohol consumption, and smoking during pregnancy, PFOS but not PFOA had a negative association with the levels of palmitic, palmitoleic, oleic, linoleic, α-linolenic, and arachidonic acids (p < 0.005) and TG (p- value = 0.016). Female infants weighed 186.6 g less with mothers whose PFOS levels were in the fourth quartile compared with the first quartile (95% CI: -363.4, -9.8). We observed no significant association between maternal levels of PFOS and birth weight of male infants. Conclusions: Our data suggest an inverse association between PFOS exposure and polyunsaturated FA levels in pregnant women. We also found a negative association between maternal PFOS levels and female birth weight.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Reproduced from Environmental Health Perspectives
EISSN
0091-6765
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1289/ehp.1408834