Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function

Shimizu, Koichi; Koji, Tochio; Kato, Yuji

Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function

Shimizu, Koichi; Koji, Tochio; Kato, Yuji

Applied Optics, 2005, 44(11), 2154-2161

Permalink : https://hdl.handle.net/2115/643

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アクセス権	open access
URI	https://hdl.handle.net/2115/643
タイトル	Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function
著者	Shimizu, Koichi ; Koji, Tochio ; Kato, Yuji
e-Rad_Researcher 30125322 著者名 Shimizu, Koichi 清水, 孝一
著者名 Koji, Tochio
著者名 Kato, Yuji
言語	英語
キーワード	Image processing : Deconvolution
	Image processing : Image reconstruction-restoration
	Medical optics and biotechnology : Image reconstruction techniques
	Medical optics and biotechnology : Light propagation in tissues
	Medical optics and biotechnology : Medical and biological imaging
	Medical optics and biotechnology : Turbid media
	scattering
	fluorescence
	imaging
	molecular imaging
	transillumination imaging
	PSF
発行日	2005-04
出版者	Optical Society of America
収録物名	Applied Optics
巻(号)	44(11)
ページ	2154-2161
抄録	The point-spread function (PSF) for transcutaneous fluorescent imaging was obtained as an analytical solution in a closed form. It is applicable to cases in which the optical property of the image-blurring turbid medium is considered to be fairly homogeneous. We proposed a technique to improve a transcutaneous image by using depth-dependent PSF. Contrast of the fluorescent image was improved for depths of 1-15 mm in a scattering medium (µ_s' = 1/mm). The visible depth was more than doubled with this technique. An experiment with a rat demonstrated considerable improvement of a transcutaneous image of the cerebral vein at a specified depth. The spread image of the heart was reduced to the correct size by use of the PSF with the actual depth of the heart.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	(c) 2005 Optical Society of America
PISSN	00036935
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1364/AO.44.002154