Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.

Katoh, Norio; Soda, Itaru; Tamamura, Hiroyasu; Takahashi, Shotaro; Uchinami, Yusuke; Ishiyama, Hiromichi; Ota, Kiyotaka; Inoue, Tetsuya; Onimaru, Rikiya; Shibuya, Keiko; Hayakawa, Kazushige; Shirato, Hiroki

Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.

Katoh, Norio; Soda, Itaru; Tamamura, Hiroyasu et al.

Radiation Oncology, 2017, 12, 3

Permalink : https://hdl.handle.net/2115/64432

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アクセス権	open access
URI	https://hdl.handle.net/2115/64432
タイトル	Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.
著者	Katoh, Norio ; Soda, Itaru ; Tamamura, Hiroyasu ; Takahashi, Shotaro ; Uchinami, Yusuke ; Ishiyama, Hiromichi ; Ota, Kiyotaka ; Inoue, Tetsuya ; Onimaru, Rikiya ; Shibuya, Keiko ; Hayakawa, Kazushige ; Shirato, Hiroki
e-Rad_Researcher 80572495 著者名 Katoh, Norio
著者名 Soda, Itaru
著者名 Tamamura, Hiroyasu
著者名 Takahashi, Shotaro
著者名 Uchinami, Yusuke
著者名 Ishiyama, Hiromichi
著者名 Ota, Kiyotaka
e-Rad_Researcher 10431363 著者名 Inoue, Tetsuya
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 50335262 著者名 Shibuya, Keiko
e-Rad_Researcher 70114189 著者名 Hayakawa, Kazushige
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Stereotactic body radiotherapy
	Non-small cell lung cancer
	Real-time tumor-tracking radiotherapy
	Gated radiotherapy
	Image-guided radiotherapy
発行日	2017-01-05
出版者	BioMed Central
収録物名	Radiation Oncology
巻(号)	12
ページ	3
抄録	Purpose: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. Materials and methods: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner. Results: From September 2000 to April 2012, 283 patients with 286 tumors were identified. The median age was 78 years (52-90) and the maximum tumor diameters were 9 to 65 mm with a median of 24 mm. The calculated biologically effective dose (10) at the isocenter using the linear-quadratic model was from 66 Gy to 126 Gy with a median of 106 Gy. With a median follow-up period of 28 months (range 0-127), the overall survival rate for the entire group, for stage IA, and for stage IB + IIA was 75%, 79%, and 65% at 2 years, and 64%, 70%, and 50% at 3 years, respectively. In the multivariate analysis, the favorable predictive factor was female for overall survival. There were no differences between the clinical outcomes at the four institutions. Grade 2, 3, 4, and 5 radiation pneumonitis was experienced by 29 (10.2%), 9 (3.2%), 0, and 0 patients. The subgroup analyses revealed that compared to margins from gross tumor volume (GTV) to planning target volume (PTV) ≥ 10 mm, margins < 10 mm did not worsen the overall survival and local control rates, while reducing the risk of radiation pneumonitis. Conclusions: This multi-institutional retrospective study showed that the results were consistent with the recent patterns-of-care and patterns-of-outcome analysis of SBRT. A prospective study will be required to evaluate SBRT using a RTRT system with margins from GTV to PTV < 10mm.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1748-717X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s13014-016-0742-3