Platelet reactivity in twin pregnancies

Umazume, Takeshi; Yamada, Takahiro; Morikawa, Mamoru; Ishikawa, Satoshi; Furuta, Itsuko; Koyama, Takahiro; Matsuno, Kazuhiko; Minakami, Hisanori

Platelet reactivity in twin pregnancies

Umazume, Takeshi; Yamada, Takahiro; Morikawa, Mamoru et al.

Thrombosis Research, 2016, 138, 43-48

Permalink : https://hdl.handle.net/2115/64445

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アクセス権	open access
URI	https://hdl.handle.net/2115/64445
タイトル	Platelet reactivity in twin pregnancies
著者	Umazume, Takeshi ; Yamada, Takahiro ; Morikawa, Mamoru ; Ishikawa, Satoshi ; Furuta, Itsuko ; Koyama, Takahiro ; Matsuno, Kazuhiko ; Minakami, Hisanori
e-Rad_Researcher 00807935 著者名 Umazume, Takeshi
e-Rad_Researcher 20419948 著者名 Yamada, Takahiro
e-Rad_Researcher 00374380 著者名 Morikawa, Mamoru
著者名 Ishikawa, Satoshi
e-Rad_Researcher 70238682 著者名 Furuta, Itsuko
著者名 Koyama, Takahiro
e-Rad_Researcher 70102332 著者名 Matsuno, Kazuhiko
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
言語	英語
キーワード	Gestational thrombocytopenia
	HELLP syndrome
	Platelet aggregation assay
	Platelet reactivity
	Soluble P-selectin
発行日	2016-02
出版者	Elsevier
収録物名	Thrombosis Research
巻(号)	138
ページ	43-48
抄録	Background: Gestational thrombocytopenia is more likely to occur in twin than singleton pregnancies. However, it is unclear whether platelets are more reactive in twin than singleton pregnancies. Methods: Changes in spontaneous platelet aggregation and concomitant fall in platelet count were examined over 90 min after blood sampling in 171 and 52 citrated whole blood (CWB) samples from 59 and 17 women with singleton and twin pregnancies, respectively. Soluble P-selectin (sP-selectin) levels in the plasma were also determined. Results: CWB 60 min after blood sampling during 2nd trimester exhibited significantly larger numbers of platelet aggregates (1297 ± 1600 vs. 497 ± 432/μl, P = 0.040) concomitant with significantly greater net decrease in platelet count (152 ± 55 vs. 115 ± 45 × 10^9/μl, P = 0.036) in twin than singleton pregnancies, respectively. This was followed by significantly lower 3rd trimester platelet count (181 ± 43 vs. 229 ± 62 × 10^9/l, P = 0.009) with significantly greater mean platelet volume (8.0 ± 1.2 vs. 7.1 ± 1.1 fl, P = 0.021) in twin than singleton pregnancies, respectively. The 3rd trimester sP-selectin per platelet was significantly higher in twin than singleton pregnancies. Conclusions: Platelets were more reactive in the 2nd trimester of twin than singleton pregnancies. This enhanced platelet reactivity may explain the decreased platelet count in the 3rd trimester of twin pregnancy.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0049-3848
関連情報	PMID 26826507
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.thromres.2015.12.019