Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Brinkman, C. Colin; Iwami, Daiki; Hritzo, Molly K. et al.

Nature communications, 2016, 7, 12021

Permalink : https://hdl.handle.net/2115/64546

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/64546
タイトル
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
著者
Brinkman, C. Colin ; Iwami, Daiki ; Hritzo, Molly K. ; Xiong, Yanbao ; Ahmad, Sarwat ; Simon, Thomas ; Hippen, Keli L. ; Blazar, Bruce R. ; Bromberg, Jonathan S.
著者名
Brinkman, C. Colin
e-Rad_Researcher
80581115
著者名
Iwami, Daiki
著者名
Hritzo, Molly K.
著者名
Xiong, Yanbao
著者名
Ahmad, Sarwat
著者名
Simon, Thomas
著者名
Hippen, Keli L.
著者名
Blazar, Bruce R.
著者名
Bromberg, Jonathan S.
言語
英語
発行日
2016-06-21
出版者
Nature Publishing Group
収録物名
Nature communications
巻(号)
7
ページ
12021
抄録
Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
2041-1723
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1038/ncomms12021