NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies : A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)

Yoshimura, Takaaki; Kinoshita, Rumiko; Onodera, Shunsuke; Toramatsu, Chie; Suzuki, Ryusuke; Ito, Yoichi M.; Takao, Seishin; Matsuura, Taeko; Matsuzaki, Yuka; Umegaki, Kikuo; Shirato, Hiroki; Shimizu, Shinichi

NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies : A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)

Yoshimura, Takaaki; Kinoshita, Rumiko; Onodera, Shunsuke et al.

Physica medica : European journal of medical physics, 2016, 32(9), 1095-1102

Permalink : https://hdl.handle.net/2115/64570

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アクセス権	open access
URI	https://hdl.handle.net/2115/64570
タイトル	NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies : A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)
著者	Yoshimura, Takaaki ; Kinoshita, Rumiko ; Onodera, Shunsuke ; Toramatsu, Chie ; Suzuki, Ryusuke ; Ito, Yoichi M. ; Takao, Seishin ; Matsuura, Taeko ; Matsuzaki, Yuka ; Umegaki, Kikuo ; Shirato, Hiroki ; Shimizu, Shinichi
著者名 Yoshimura, Takaaki
e-Rad_Researcher 70507582 著者名 Kinoshita, Rumiko
著者名 Onodera, Shunsuke
著者名 Toramatsu, Chie
e-Rad_Researcher 00400052 著者名 Suzuki, Ryusuke
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 10614216 著者名 Takao, Seishin
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
著者名 Matsuzaki, Yuka
著者名 Umegaki, Kikuo
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
言語	英語
キーワード	Whole pelvic radiation therapy
	Spot-scanning proton therapy
	LKB-NTCP model analysis
	Treatment planning study
発行日	2016-09
出版者	Elsevier
収録物名	Physica medica : European journal of medical physics
巻(号)	32(9)
ページ	1095-1102
抄録	Purpose: This treatment planning study was conducted to determine whether spot scanning proton beam therapy (SSPT) reduces the risk of grade ⩾3 hematologic toxicity (HT3+) compared with intensity modulated radiation therapy (IMRT) for postoperative whole pelvic radiation therapy (WPRT). Methods and materials: The normal tissue complication probability (NTCP) of the risk of HT3+ was used as an in silico surrogate marker in this analysis. IMRT and SSPT plans were created for 13 gynecologic malignancy patients who had received hysterectomies. The IMRT plans were generated using the 7-fields step and shoot technique. The SSPT plans were generated using anterior-posterior field with single field optimization. Using the relative biological effectives (RBE) value of 1.0 for IMRT and 1.1 for SSPT, the prescribed dose was 45 Gy(RBE) in 1.8 Gy(RBE) per fractions for 95% of the planning target volume (PTV). The homogeneity index (HI) and the conformity index (CI) of the PTV were also compared. Results: The bone marrow (BM) and femoral head doses using SSPT were significantly lower than with IMRT. The NTCP modeling analysis showed that the risk of HT3+ using SSPT was significantly lower than with IMRT (NTCP = 0.04 ± 0.01 and 0.19 ± 0.03, p = 0.0002, respectively). There were no significant differences in the CI and HI of the PTV between IMRT and SSPT (CI = 0.97 ± 0.01 and 0.96 ± 0.02, p = 0.3177, and HI = 1.24 ± 0.11 and 1.27 ± 0.05, p = 0.8473, respectively). Conclusion: The SSPT achieves significant reductions in the dose to BM without compromising target coverage, compared with IMRT. The NTCP value for HT3+ in SSPT was significantly lower than in IMRT.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1120-1797
関連情報	PMID 27567089
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.ejmp.2016.08.007