open access

https://hdl.handle.net/2115/64597

Differential Contributions of GABA Concentration in Frontal and Parietal Regions to Individual Differences in Attentional Blink

英語

visual attention

2016-08-25

Society for Neuroscience

Journal of neuroscience

36(34)

8895-8901

Selective attention plays an important role in identifying transient objects in a complex visual scene. Attentional control ability varies with observers. However, it is unclear what neural mechanisms are responsible for individual differences in attentional control ability. The present study used the following attentional blink paradigm: when two targets are to be identified in rapid serial visual presentation, the processing of the first target interrupts the identification of the second one appearing within 500 ms after the first-target onset. It has been assumed that the reduction of the second-target accuracy is mainly due to a transient inhibition of attentional reorienting from the first to the second target, which is modulated by the GABA system. Using magnetic resonance spectroscopy, we investigated whether individual variation of attentional blink magnitude is associated with GABA concentrations in the left prefrontal cortex (PFC), right posterior-parietal cortex (PPC), and visual cortex (VC) of humans. GABA concentrations in the PFC were related negatively to attentional blink magnitude and positively to the first-target accuracy. GABA concentrations in the PPC were positively correlated with attentional blink magnitude. However, GABA concentrations in the VC did not contribute to attentional blink magnitude and first-target accuracy. Our results suggest that frontoparietal inhibitory mechanisms are closely linked with individual differences in attentional processing and that functional roles of the GABAergic system in selective attention differ between the PFC and PPC.

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