open access

https://hdl.handle.net/2115/64884

Synthesis of Photoreactive 2-Phenethylamine Derivatives : Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

英語

Adenosine receptors

2013-04

Wiley-VCH

European Journal of Organic Chemistry

2013(12)

2428-2433

2-Phenylethylamine is well known as a substructure of many biologically active compounds, and the synthesis of its photoreactive derivatives to allow the analysis of biological functions is reported. This allowed us to synthesise ligands for adenosine receptors, which have many functional roles in biology and have been extensively studied for their many roles in maintaining homeostasis. Adenosine is one of the most common biochemical compounds, but photoaffinity labeling has not yet been used to study adenosine receptors. Synthetic methods for producing photoreactive adenosine derivatives that can be used with adenosine receptors were established for the photophores phenyl azide and benzophenone. The effect of the introduction of the photoreactive components was determined using an adenosine receptor assay.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Synthesis of Photoreactive 2-Phenethylamine Derivatives - Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling,European Journal of Organic Chemistry, 2013(12), 2428-2433, which has been published in final form at 10.1002/ejoc.201201657. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

1434-193X