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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/64895
タイトル	Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1
著者	Togi, Sumihito ; Hatano, Yosuke ; Muromoto, Ryuta ; Kawanishi, Eri ; Ikeda, Osamu ; Hirashima, Koki ; Kon, Shigeyuki ; Kitai, Yuichi ; Yasui, Teruhito ; Oritani, Kenji ; Matsuda, Tadashi
著者名 Togi, Sumihito
著者名 Hatano, Yosuke
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
著者名 Kawanishi, Eri
著者名 Ikeda, Osamu
著者名 Hirashima, Koki
e-Rad_Researcher 90344499 著者名 Kon, Shigeyuki
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
e-Rad_Researcher 60283074 著者名 Yasui, Teruhito
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	caspase
	degradation
	EBV
	LMP1
	NF-kappa B activation
発行日	2016-03
出版者	Wiley-Blackwell
収録物名	FEBS Letters
巻(号)	590(6)
ページ	808-818
抄録	Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) plays pathogenic roles in EBV-related diseases. Thus, host cells employ several mechanisms to regulate LMP1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as BS69. Here, we found that caspase-3 mainly degraded LMP1 proteins in HeLa cells, leading to decreased NF-kappa B and STAT3 activation. Caspase-3 cleaved the consensus DNTD sequences in the CTAR3 region of LMP1. Of importance, LMP1 expression strongly enhanced caspase-3 activity. Taken together, the reduction of LMP1 protein levels by caspases is likely to be a newly identified host defense against EBV infection.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1, FEBS Letters590(6), pp808-818, 2016, which has been published in final form at 10.1002/1873-3468.12119. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	0014-5793
関連情報	PMID 26921582
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/1873-3468.12119

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