Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease

Kitta, Takeya; Chancellor, Michael B.; de Groat, William C.; Shinohara, Nobuo; Yoshimura, Naoki

Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease

Kitta, Takeya; Chancellor, Michael B.; de Groat, William C. et al.

Journal of urology, 2016, 195(5), 1613-1620

Permalink : https://hdl.handle.net/2115/65176

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アクセス権	open access
URI	https://hdl.handle.net/2115/65176
タイトル	Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease
著者	Kitta, Takeya ; Chancellor, Michael B. ; de Groat, William C. ; Shinohara, Nobuo ; Yoshimura, Naoki
e-Rad_Researcher 40374441 著者名 Kitta, Takeya
著者名 Chancellor, Michael B.
著者名 de Groat, William C.
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
著者名 Yoshimura, Naoki
言語	英語
キーワード	urinary bladder, overactive
	Parkinson disease
	gyrus cinguli
	adenosine
	ZM 241385
	Parkinson's disease
	OAB
	anterior cingulate cortex
	evoked potential
発行日	2016-05
出版者	Elsevier
収録物名	Journal of urology
巻(号)	195(5)
ページ	1613-1620
抄録	Purpose: The present study examined dynamic changes in neural activity of the anterior cingulate cortex (ACC) and the midbrain periaqueductal gray (PAG) during the micturition reflex in a Parkinson's disease (PD) model as well as the effects of direct stimulation of the ACC on the micturition reflex. Materials and Methods: Electrodes were inserted into the ACC or the PAG, and the effects of intravenous (i.v.) administration of ZM24138 (ZM: adenosine A2A receptor antagonist) on the pelvic nerve evoked field potentials were examined. The effect of electrical stimulation of the ACC was also examined. Results: PD rats showed bladder overactivity evidenced by a significant decrease in intercontraction intervals (ICI) compared with sham rats. I.v. administration of ZM increased ICI in both groups with the inhibitory effects being greater in PD; and dose-dependently increased the amplitude of evoked potentials in the ACC of PD rats but not in sham rats. I.v. administration of ZM reduced the evoked potential amplitude in the PAG of both groups with the inhibitory effects being greater in PD vs. sham rats. Electrical stimulation of the ACC significantly increased ICI. Conclusions: These results suggest that ACC neurons have an inhibitory role in bladder control because neural activity in the ACC was significantly increased along with suppression of bladder overactivity after ZM administration in the PD model, and the stimulation of the ACC inhibited the micturition reflex. Understanding the roles of the ACC in the modulation of micturition could provide further insights into the pathophysiology of OAB.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0022-5347
NCID	AA00708666
関連情報	PMID 26626223
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.juro.2015.11.039