Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index : The Hokkaido Study

Kobayashi, Sachiko; Azumi, Kaoru; Goudarzi, Houman; Araki, Atsuko; Miyashita, Chihiro; Kobayashi, Sumitaka; Itoh, Sachiko; Sasaki, Seiko; Ishizuka, Mayumi; Nakazawa, Hiroyuki; Ikeno, Tamiko; Kishi, Reiko

Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index : The Hokkaido Study

Kobayashi, Sachiko; Azumi, Kaoru; Goudarzi, Houman et al.

Journal of Exposure Science and Environmental Epidemiology, 2017, 27(3), 251-259

Permalink : https://hdl.handle.net/2115/65204

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アクセス権	open access
URI	https://hdl.handle.net/2115/65204
タイトル	Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index : The Hokkaido Study
その他のタイトル	Prenatal PFAAs exposure and IGF2/H19 methylation
著者	Kobayashi, Sachiko ; Azumi, Kaoru ; Goudarzi, Houman ; Araki, Atsuko ; Miyashita, Chihiro ; Kobayashi, Sumitaka ; Itoh, Sachiko ; Sasaki, Seiko ; Ishizuka, Mayumi ; Nakazawa, Hiroyuki ; Ikeno, Tamiko ; Kishi, Reiko
著者名 Kobayashi, Sachiko
e-Rad_Researcher 90221720 著者名 Azumi, Kaoru
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
e-Rad_Researcher 50150173 著者名 Nakazawa, Hiroyuki
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	epidemiology
	perfluorinated chemicals
	child exposure/health
	endocrine disruptors
	DNA methylation
	birth cohort
発行日	2017-05
出版者	Nature Publishing Group
収録物名	Journal of Exposure Science and Environmental Epidemiology
巻(号)	27(3)
ページ	251-259
抄録	Prenatal exposure to perfluoroalkyl acids (PFAAs) influences fetal growth and long-term health. However, whether PFAAs affect offspring DNA methylation patterns to influence health outcomes is yet to be evaluated. Here, we assessed effect of prenatal PFAA exposure on cord blood insulin-like growth factor 2 (IGF2), H19, and long interspersed element 1 (LINE1) methylation and its associations with birth size. Mother-child pairs (N=177) from the Hokkaido Study on Environment and Children's Health were included in the study. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels in maternal serum were measured by liquid chromatography-tandem mass spectrometry. IGF2, H19, and LINE1 methylation in cord blood DNA was determined by pyrosequencing. After full adjustment in multiple linear regression models, IGF2 methylation showed a significant negative association with log-unit increase in PFOA (partial regression coefficient=-0.73; 95% confidence interval: -1.44 to -0.02). Mediation analysis suggested that reduced IGF2 methylation explained approximately 21% of the observed association between PFOA exposure and reduced ponderal index of the infant at birth. These results indicated that the effects of prenatal PFOA exposure could be mediated through DNA methylation. Further study will be required to determine the potential for long-term adverse health effects of reduced IGF2 methylation induced by PFOA exposure.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1559-0631
EISSN	1559-064X
関連情報	PMID 27553991
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/jes.2016.50