ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia

Habiba, Umma; Hida, Kyoko; Kitamura, Tetsuya; Yanagawa Matsuda, Aya; Higashino, Fumihiro; Ito, Yoichi M.; Ohiro, Yoichi; Totsuka, Yasunori; Shindoh, Masanobu

ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia

Habiba, Umma; Hida, Kyoko; Kitamura, Tetsuya et al.

Oncology Letters, 2017, 13(1), 321-328

Permalink : https://hdl.handle.net/2115/65241

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アクセス権	open access
URI	https://hdl.handle.net/2115/65241
タイトル	ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia
著者	Habiba, Umma ; Hida, Kyoko ; Kitamura, Tetsuya ; Yanagawa Matsuda, Aya ; Higashino, Fumihiro ; Ito, Yoichi M. ; Ohiro, Yoichi ; Totsuka, Yasunori ; Shindoh, Masanobu
著者名 Habiba, Umma
e-Rad_Researcher 40399952 著者名 Hida, Kyoko
e-Rad_Researcher 00451451 著者名 Kitamura, Tetsuya
e-Rad_Researcher 60514312 著者名 Yanagawa Matsuda, Aya
e-Rad_Researcher 50301891 著者名 Higashino, Fumihiro
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 40301915 著者名 Ohiro, Yoichi
e-Rad_Researcher 00109456 著者名 Totsuka, Yasunori
e-Rad_Researcher 20162802 著者名 Shindoh, Masanobu
言語	英語
キーワード	oral leukoplakia
	malignant transformation
	ALDH1
	podoplanin
	cancer stem cell
発行日	2017-01
出版者	Spandidos Publications
収録物名	Oncology Letters
巻(号)	13(1)
ページ	321-328
抄録	Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. In the present study, the expression patterns of ALDH1 and podoplanin were determined in samples from 79 patients with OL. The association between protein expression and clinicopathological parameters, including oral cancer-free survival, was analyzed during a mean follow-up period of 3.4 years. Expression of ALDH1 and podoplanin was observed in 61 and 67% patients, respectively. Kaplan-Meier analysis demonstrated that the expression of the proteins was correlated with the risk of progression to oral cancer. Multivariate analysis revealed that expression of ALDH1 and podoplanin was associated with 3.02- and 2.62-fold increased risk of malignant transformation, respectively. The malignant transformation risk of OL was considerably higher in cases with expression of both proteins. Point-prevalence analysis revealed that 66% of patients with co-expression of ALDH1 and podoplanin developed oral cancer. Taken together, our data indicate that ALDH1 and podoplanin expression patterns in OL are associated with oral cancer development, suggesting that ALDH1 and podoplanin may be useful biomarkers to identify OL patients with a substantially high oral cancer risk.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1792-1074
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/ol.2016.5379