原因薬物変更後に全顎的に著明な歯肉腫脹を呈した薬物性歯肉増殖症の１例

gingival hyperplasia

北海道歯学会

北海道歯学雑誌

In this study we report on a case of drug-induced gingival overgrowth exacerbated after changing thecausative drug, which was successfully treated. 　An 82-year-old woman was aware of gingival swelling ten years before and had been treated by periodontal initial therapy at a dental clinic several times a year. She changed from a calcium channel blocker (amlodipine) to an angiotensin II receptor blocker (olmesartan) by an internal medicine doctor three after, but there were no improvements of the symptoms. Three years later, she complained of an eating disorder caused by severe exacerbated gingival overgrowth and was referred to our department. During the first examination, marked nodular pedunculated gingival swelling of the whole alveolar region in both the labial and lingual sides of her lower and upper teeth was observed. Swollen gingiva had covered almost the entire crown of the left maxillary and mandibular molars. The gingival surface was smooth and its elasticity was relatively hard. Periodontal examination revealed that tooth mobility was within the 2-3 class and the probing depth was greater than 8 mm in all sites but the anterior teeth. As a malignant lesion was ruled out by a blood test and pathological examination, she underwent an operation to extract all of her teeth, gingivectomy, and gingivoplasty under general anesthesia. We began to fabricate maxillary and mandibular complete dentures one month after the operation. The dentures were fitted one month after the start of fabrication. There was no recurrence more than one year after operation.