Expression of Notch1 and Numb in small cell lung cancer

Kikuchi, Hajime; Sakakibara-Konishi, Jun; Furuta, Megumi et al.

Oncotarget, 2017, 8(6), 10348-10358

Permalink : https://hdl.handle.net/2115/65667

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アクセス権
open access
URI
https://hdl.handle.net/2115/65667
タイトル
Expression of Notch1 and Numb in small cell lung cancer
著者
Kikuchi, Hajime ; Sakakibara-Konishi, Jun ; Furuta, Megumi ; Yokouchi, Hiroshi ; Nishihara, Hiroshi ; Yamazaki, Shigeo ; Uramoto, Hidetaka ; Tanaka, Fumihiro ; Harada, Masao ; Akie, Kenji ; Sugaya, Fumiko ; Fujita, Yuka ; Takamura, Kei ; Kojima, Tetsuya ; Harada, Toshiyuki ; Higuchi, Mitsunori ; Honjo, Osamu ; Minami, Yoshinori ; Watanabe, Naomi ; Oizumi, Satoshi ; Suzuki, Hiroyuki ; Ishida, Takashi ; Dosaka-Akita, Hirotoshi ; Isobe, Hiroshi ; Munakata, Mitsuru ; Nishimura, Masaharu
著者名
Kikuchi, Hajime
e-Rad_Researcher
50374278
著者名
Sakakibara-Konishi, Jun
著者名
Furuta, Megumi
著者名
Yokouchi, Hiroshi
e-Rad_Researcher
50322805
著者名
Nishihara, Hiroshi
著者名
Yamazaki, Shigeo
著者名
Uramoto, Hidetaka
著者名
Tanaka, Fumihiro
著者名
Harada, Masao
著者名
Akie, Kenji
著者名
Sugaya, Fumiko
著者名
Fujita, Yuka
著者名
Takamura, Kei
著者名
Kojima, Tetsuya
著者名
Harada, Toshiyuki
著者名
Higuchi, Mitsunori
著者名
Honjo, Osamu
著者名
Minami, Yoshinori
著者名
Watanabe, Naomi
e-Rad_Researcher
10421968
著者名
Oizumi, Satoshi
著者名
Suzuki, Hiroyuki
著者名
Ishida, Takashi
e-Rad_Researcher
70222528
著者名
Dosaka-Akita, Hirotoshi
e-Rad_Researcher
90241322
著者名
Isobe, Hiroshi
著者名
Munakata, Mitsuru
著者名
Nishimura, Masaharu
言語
英語
キーワード
small cell lung cancer
Notch1
Numb
immunohistochemistry
surgery
発行日
2017-02-07
出版者
Impact Journals
収録物名
Oncotarget
巻(号)
8(6)
ページ
10348-10358
抄録
Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 3.0 Unported
PISSN
1949-2553
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.18632/oncotarget.14411