The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

Yoshida, Sumito; Shime, Hiroaki; Funami, Kenji; Takaki, Hiromi; Matsumoto, Misako; Kasahara, Masanori; Seya, Tsukasa

The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

Yoshida, Sumito; Shime, Hiroaki; Funami, Kenji et al.

PLoS ONE, 2017, 12(1), e0169360

Permalink : https://hdl.handle.net/2115/65671

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pone.0169360.s003	tif	172 KB	252	Supplementary figure 3

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/65671
タイトル	The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
著者	Yoshida, Sumito ; Shime, Hiroaki ; Funami, Kenji ; Takaki, Hiromi ; Matsumoto, Misako ; Kasahara, Masanori ; Seya, Tsukasa
著者名 Yoshida, Sumito
e-Rad_Researcher 70372133 著者名 Shime, Hiroaki
e-Rad_Researcher 00421983 著者名 Funami, Kenji
著者名 Takaki, Hiromi
e-Rad_Researcher 30332456 著者名 Matsumoto, Misako
e-Rad_Researcher 30241318 著者名 Kasahara, Masanori
e-Rad_Researcher 10301805 著者名 Seya, Tsukasa
言語	英語
発行日	2017-01-23
出版者	The Public Library of Science
収録物名	PLoS ONE
巻(号)	12(1)
ページ	e0169360
抄録	L-Ergothioneine (EGT) is a naturally-occurring amino acid which is characterized by its antioxidant property; yet, the physiological role of EGT has yet to be established. We investigated the immune-enhancing properties of EGT, and found that it acts as a potentiator of toll-like receptor (TLR) signaling. When mouse bone marrow-derived macrophages (BMDMs) were pretreated with EGT, TLR signal-mediated cytokine production was augmented in BMDMs. The results were reproducible with TLR2, 3, 4 and 7 agonists. In particular, IL-6 and IL-12p40 were elevated further by pretreatment with EGT in BMDMs, suggesting the induction of M1 polarization. In co-culture assay with OT-II CD4+ T cells and splenic F4/80+ macrophages, EGT significantly induced Th17 skewing in CD4+ T cells. Thus, EGT is an immune modifier as well as a redox controller under TLR stimulation that induces M1 macrophages and a Th17 shift in inflammation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0169360